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CYTOTOXICITY OF METABOLITES PRODUCED BY ENDOPHYTIC FUNGUS CLADOSPORIUM SP. ISOLATED FROM MARINE MACROALGAE ON IN­VITRO MCF­7, HELA, AND DU-145 CELL LINES
Objective: To investigate the in vitro cytotoxicity effect of the crude ethyl acetate extract of Cladosporium sp. on MCF-7, HeLa, and DU-145 cell lines.Methods: In vitro cytotoxicity was evaluated by…
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Synthesis of t-Butyl (2R)-Hydroxyisovalerate, A Precursor of Aureobasidin B
TLDR
The aim of this research is to synthesise a precursor of aureobasidin B, t-butyl (2R)-hydroxyisovalerate (t-Bu-Hiv), that is prepared for the total synthesis of a Aureobasido B, and to characterize the synthesized products by various spectroscopic techniques.
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The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies
TLDR
The catechin is predicted to have potential as a new natural inhibitor of the MurA enzyme to inhibit bacterial cell wall biosynthesis.
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Cytotoxic Assay From Stem Bark Aglaia minahassae and Aglaia simplicifolia Against HeLa Cervical Cancer Cell Lines
TLDR
This research showed that A. minahassae’s most cytotoxic extract extract against HeLa cell lines was n -hexane and n -buthanol, while A. sim- plicifolia most cytosine extract extract was n- hexane (IC 50 = 23.3098 μ g/mL).
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Triterpenoids from Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells
The diversity of structures of triterpenoids provides a variety of interesting pharmacological effects, one of them being anticancer. Sources of triterpenoids are found in Dysoxylum excelsum, it is…
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7-HIDROKSI-6-METOKSI KUMARIN (SKOPOLETIN) DARI KULIT BATANG Chisocheton celebicus (MELIACEAE)
TLDR
The chemical structure of 7-hydroxy-6-methoxy coumarin was identified on the basis of spectroscopic data including UV, IR, 1D-NMR, 2D- NMR and mass along with by comparison with those spectral data previously reported.
Dammarane-Type Triterpenoids from The Stembark of Aglaia argentea (Meliaceae)
Two dammarane-type triterpenoids, 20S,24S-epoxy-3α,25-dihydroxydammarane (1) and 3α-acetyl-20S,24S-epoxy-3α,25-dihydroxydammarane (2), have been isolated from the stembark of Aglaia argentea. The…
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Anti-Cancer Assessment of a Ramie (Boehmeria nivea L. Gaud.) Leaf Extract Using Mcf-7 Cell Line and a Yeast-Based Bioassay
TLDR
The CH2Cl2 fraction of Ramie leaves can inhibits the proliferation of MCF-7 cells in the active and strong categories and showed potential as an anticancer drug candidate.
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TRITERPENOID DAMMARANS FROM THE BARK OF AGLAIA SMITHII ( MELIACEAE ) AND THEIR TOXIC ACTIVITY AGAINST ARTEMIA SALINA AND CYTOTOXIC ACTIVITY AGAINST MURINE LEUKEMIA CELLS P-388
Aglaia smithii is a higher plant belonging to Meliaceae family and widely distributed in South East Asia. Plants of Meliaceae family were known as a source of cytotoxic (anticancer) substances. The…
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