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CYTOTOXICITY OF METABOLITES PRODUCED BY ENDOPHYTIC FUNGUS CLADOSPORIUM SP. ISOLATED FROM MARINE MACROALGAE ON INVITRO MCF7, HELA, AND DU-145 CELL LINES
- A. P. Wulandari, R. R. I. N. Examinati, M. ., D. H. P. Huspa, P. Andayaningsih
- BiologyInternational Journal of Pharmacy and…
- 1 August 2018
Objective: To investigate the in vitro cytotoxicity effect of the crude ethyl acetate extract of Cladosporium sp. on MCF-7, HeLa, and DU-145 cell lines.Methods: In vitro cytotoxicity was evaluated by…
Synthesis of t-Butyl (2R)-Hydroxyisovalerate, A Precursor of Aureobasidin B
The aim of this research is to synthesise a precursor of aureobasidin B, t-butyl (2R)-hydroxyisovalerate (t-Bu-Hiv), that is prepared for the total synthesis of a Aureobasido B, and to characterize the synthesized products by various spectroscopic techniques.
The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies
The catechin is predicted to have potential as a new natural inhibitor of the MurA enzyme to inhibit bacterial cell wall biosynthesis.
Cytotoxic Assay From Stem Bark Aglaia minahassae and Aglaia simplicifolia Against HeLa Cervical Cancer Cell Lines
- Nunung Kurniasih, Hersa Milawati, M. Fajar, R. Abdulah, D. H. P. Huspa, U. Supratman
- 28 June 2018
This research showed that A. minahassae’s most cytotoxic extract extract against HeLa cell lines was n -hexane and n -buthanol, while A. sim- plicifolia most cytosine extract extract was n- hexane (IC 50 = 23.3098 μ g/mL).
Triterpenoids from Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells
- S. R. Meilanie, Tri Mayanti, Jamaludin Al Anshori
- ChemistryIndonesian Journal of Chemistry
- 12 July 2022
The diversity of structures of triterpenoids provides a variety of interesting pharmacological effects, one of them being anticancer. Sources of triterpenoids are found in Dysoxylum excelsum, it is…
7-HIDROKSI-6-METOKSI KUMARIN (SKOPOLETIN) DARI KULIT BATANG Chisocheton celebicus (MELIACEAE)
The chemical structure of 7-hydroxy-6-methoxy coumarin was identified on the basis of spectroscopic data including UV, IR, 1D-NMR, 2D- NMR and mass along with by comparison with those spectral data previously reported.
Dammarane-Type Triterpenoids from The Stembark of Aglaia argentea (Meliaceae)
Two dammarane-type triterpenoids, 20S,24S-epoxy-3α,25-dihydroxydammarane (1) and 3α-acetyl-20S,24S-epoxy-3α,25-dihydroxydammarane (2), have been isolated from the stembark of Aglaia argentea. The…
Anti-Cancer Assessment of a Ramie (Boehmeria nivea L. Gaud.) Leaf Extract Using Mcf-7 Cell Line and a Yeast-Based Bioassay
- Asri Peni Wulandari, Annisa Abdiwijaya Qaromah, Karen Kezia Lolowang, D. H. P. Huspa, Ade Zuhrotun
- BiologyIndonesian Journal of Medical Sciences and Public…
- 23 November 2021
The CH2Cl2 fraction of Ramie leaves can inhibits the proliferation of MCF-7 cells in the active and strong categories and showed potential as an anticancer drug candidate.
TRITERPENOID DAMMARANS FROM THE BARK OF AGLAIA SMITHII ( MELIACEAE ) AND THEIR TOXIC ACTIVITY AGAINST ARTEMIA SALINA AND CYTOTOXIC ACTIVITY AGAINST MURINE LEUKEMIA CELLS P-388
Aglaia smithii is a higher plant belonging to Meliaceae family and widely distributed in South East Asia. Plants of Meliaceae family were known as a source of cytotoxic (anticancer) substances. The…