• Publications
  • Influence
Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
The eighth iteration of the American College of Chest Physicians Antithrombotic Guidelines presented, in a paper version, a narrative evidence summary and rationale for the recommendations, a smallExpand
  • 1,273
  • 48
  • PDF
Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines.
Pulmonary arterial hypertension (PAH) occurs as an idiopathic process or as a component of a variety of disease processes, including chronic thromboembolic disease, connective tissue diseases,Expand
  • 869
  • 35
  • PDF
Prevalence of the Female Athlete Triad in High School Athletes and Sedentary Students
Objective:To determine the prevalence of the female athlete triad (low energy availability, menstrual dysfunction, and low bone mineral density) in high school varsity athletes in a variety of sportsExpand
  • 160
  • 26
Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force.
While grading the strength of recommendations and the quality of underlying evidence enhances the usefulness of clinical guidelines, the profusion of guideline grading systems undermines the value ofExpand
  • 1,119
  • 23
  • PDF
Role for Hydrogen Peroxide in Flow-Induced Dilation of Human Coronary Arterioles
Abstract— Flow-induced dilation (FID) is dependent largely on hyperpolarization of vascular smooth muscle cells (VSMCs) in human coronary arterioles (HCA) from patients with coronary disease. AnimalExpand
  • 425
  • 23
  • PDF
Mitochondrial reactive oxygen species-mediated signaling in endothelial cells.
Once thought of as toxic by-products of cellular metabolism, reactive oxygen species (ROS) have been implicated in a large variety of cell-signaling processes. Several enzymatic systems contribute toExpand
  • 380
  • 20
  • PDF
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress.
The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the endothelial shear response and flow-mediated dilation, although the precise functions of this channelExpand
  • 221
  • 15
  • PDF
Transient Receptor Potential Vanilloid Type 4–Deficient Mice Exhibit Impaired Endothelium-Dependent Relaxation Induced by Acetylcholine In Vitro and In Vivo
Agonist-induced Ca2+ entry is important for the synthesis and release of vasoactive factors in endothelial cells. The transient receptor potential vanilloid type 4 (TRPV4) channel, a Ca2+-permeantExpand
  • 153
  • 15
  • PDF
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.
Atherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The intermediate-conductance calcium-activated potassium channelExpand
  • 187
  • 13
  • PDF
ACCP Standard Patient Category Recommended Protocol Standard for Acute , Critical & Chronic Patients 9 . 3 Treatment of Anticoagulant-Related Bleeding Acutely
9.3 Treatment of AnticoagulantRelated Bleeding Acutely Ill Hospitalized Medical Patients 2.7.2. For acutely ill hospitalized medical patients at increased risk of thrombosis who are bleeding or atExpand
  • 110
  • 11
  • PDF