• Publications
  • Influence
A default mode of brain function.
A baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF is identified, suggesting the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors. Expand
Searching for a baseline: Functional imaging and the resting human brain
This work explores the possibility that there might be a baseline or resting state of brain function involving a specific set of mental operations, including the manner in which a baseline is defined and the implications of such a baseline for the understanding ofbrain function. Expand
Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function
The presence of self-referential mental activity appears to be associated with increases from the baseline in dorsal MPFC, and reductions in ventral MPFC occurred consistent with the fact that attention-demanding tasks attenuate emotional processing. Expand
Appraising the brain's energy budget
  • M. Raichle, D. Gusnard
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 29 July 2002
New information is provided on the relationship between brain energy metabolism and cellular activity and how this relates to transient changes in activity that have been generally termed ‘‘activations’’ in this issue of PNAS. Expand
Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety.
Regional cerebral blood flow was examined in the human medial prefrontal cortex with positron emission tomography during anticipatory anxiety and changes in MPFC and in the midbrain were correlated with each other and with anxiety self rating. Expand
Persistence and brain circuitry
It is shown that individual differences in Persistence, a dimensional trait assessed with a seven-factor personality model, may be linked to specific areas in the lateral orbital and medial prefrontal cortex and the ventral striatum and this finding represents a fresh approach to linking normalindividual differences in personality and behavior to specific neuronal structures and subsystems. Expand
Being a self: Considerations from functional imaging
  • D. Gusnard
  • Medicine, Psychology
  • Consciousness and Cognition
  • 1 December 2005
Functional brain imaging data are reviewed and a hypothesis presented regarding a significant role for these areas in enabling degrees of self-awareness and participating in the management of such behavioral control. Expand
The Emotional Modulation of Cognitive Processing: An fMRI Study
Results provide evidence that the emotional valence and arousing nature of stimuli used during the performance of an attention-demanding cognitive task are reflected in discernable, quantitative changes in the functional anatomy associated with task performance. Expand
Transient BOLD responses at block transitions
A systematic study of block-transition transient responses obtained using four widely divergent tasks defines transient response topography and examines the extent to which these responses vary across different tasks and between block onset and offset. Expand
Intrinsic brain activity sets the stage for expression of motivated behavior
It is suggested that the manner in which constraint and potential modulation is achieved likely involves processes that emerge from the coordinated behavior of multiple brain systems, and functional brain imaging techniques such as PET and fMRI are beginning to help us understand aspects of such coordination. Expand