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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients
ABSTRACT Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identifyExpand
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Weekend effect in diurnal temperature range in China: Opposite signals between winter and summer
[1] Intense human activity can impact weather and climate in many ways. One possible important consequence is the weekly cycle (so-called weekend effect) in the diurnal temperature range (DTR). TheExpand
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Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.
The association and dissociation kinetics of ligands binding to proteins vary considerably, but the mechanisms behind this variability are poorly understood, limiting their utilization for drugExpand
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Spring Arctic Oscillation-East Asian summer monsoon connection through circulation changes over the western North Pacific
In the present study the links between spring Arctic Oscillation (AO) and East Asian summer monsoon (EASM) was investigated with focus on the importance of the North Pacific atmospheric circulationExpand
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The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers
  • Guo Wang, H. Lei, +7 authors H. Zhou
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
  • 1 March 2009
AimTo study the pharmacokinetic characteristics of voriconazole in healthy Chinese male volunteers in relation to cytochrome P450 (CYP) 2C19 genotype status, including ultra-rapid metabolizersExpand
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Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism.
BACKGROUND Both atorvastatin and rifampicin are substrates of OATP1B1 (organic anion transporting polypeptide 1B1) encoded by SLCO1B1 gene. Rifampicin is a potent inhibitor of SLCO1B1 (IC50 1.5Expand
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Drug‐Target Residence Time—A Case for G Protein‐Coupled Receptors
A vast number of marketed drugs act on G protein‐coupled receptors (GPCRs), the most successful category of drug targets to date. These drugs usually possess high target affinity and selectivity, andExpand
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Fecal Microbiota Transplantation Improves the Quality of Life in Patients with Inflammatory Bowel Disease
  • Yao Wei, W. Zhu, +4 authors J. Li
  • Medicine
  • Gastroenterology research and practice
  • 4 June 2015
Introduction. To determine the effect of fecal microbiota transplantation (FMT) on quality of life (QoL) in patients with inflammatory bowel disease (IBD). Methods. Fourteen IBD patients, includingExpand
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ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens
ABSTRACT Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR,Expand
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Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes.
BACKGROUND PPIs are widely used in peptic diseases, and this paper is to investigate the kinetic characteristics of a new PPI ilaprazole in Chinese healthy subjects and the association with CYP3A5Expand
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