• Publications
  • Influence
Design, synthesis and characterization of captopril prodrugs for enhanced percutaneous absorption
Most drugs are designed primarily for oral administration, but the activity and stability profiles desirable for this route often make them unsuitable for transdermal delivery. We were thereforeExpand
  • 47
  • 2
Toxicokinetics of Deltamethrin: Dosage Dependency, Vehicle Effects, and Low-Dose Age-Equivalent Dosimetry in Rats
There is increasing concern that infants and children may be at increased risk of neurological effects of pyrethroids, the most widely used class of insecticide. The objectives of this investigationExpand
  • 13
  • 1
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
A C2/C2'-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer 4b (DRG-16) with a C8-O(CH2)nO-C8' diether linkage (n = 5) has been synthesized that shows markedly superior in vitro cytotoxicExpand
  • 74
Determination of deltamethrin in rat plasma and brain using gas chromatography-negative chemical ionization mass spectrometry.
Quantification of the pyrethroid deltamethrin (DLM) in small (100 μL) biological samples from rodents is essential for toxicokinetic studies of trace levels of the insecticide in foods. SuchExpand
  • 13
Chromatographic methods for the bioanalysis of pyrethroid pesticides.
Reliable analytical methods are needed for the determination of pyrethroid pesticides residues in biological tissues such as whole blood and plasma, meat, eggs, milk, brain, liver, and adipose tissueExpand
  • 19
Formulation and characterization of a captopril ethyl ester drug-in-adhesive-type patch for percutaneous absorption
Background: The ethyl ester of captopril has been shown to exhibit enhanced permeation across human skin compared to the parent drug. A drug-in-adhesive patch formulation of a captopril ethyl esterExpand
  • 16
Predictive Methods in Percutaneous Absorption
The first € price and the £ and $ price are net prices, subject to local VAT. Prices indicated with * include VAT for books; the €(D) includes 7% for Germany, the €(A) includes 10% for Austria.Expand
  • 15
  • PDF
Quantitation of Deltamethrin in Rat Liver and Muscle Homogenates Using Dispersive Solid-Phase Extraction with GC-NCI-MS.
An improved bioanalytical method to determine pyrethroids from small-volume (300 μL) rat liver and muscle homogenates was developed, validated, and applied to small-animal studies. The method usedExpand
  • 7
Influence of Maturation on In Vivo Tissue to Plasma Partition Coefficients for Cis- and Trans-Permethrin.
Permethrin, the most widely used household insecticide in the United States, is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation is toExpand
  • 7
The application of gaussian processes in the prediction of permeability across a polydimethlysiloxane membrane
Polydimethylsiloxane (PDMS) silicone membranes, such as Silastic®, have been used widely in place of mammalian tissue in the determination of percutaneous absorption. While many experiments haveExpand
  • 1