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Principles and standards for reporting animal experiments in The Journal of Physiology and Experimental Physiology
  • D. Grundy
  • Medicine
    The Journal of physiology
  • 15 June 2015
TLDR
Detailed guidelines for how authors should report experimental procedures that involve animals are set out to facilitate the review process and decision making where there are questions regarding animal ethics.
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome.
TLDR
Mucosal mast cell mediators from IBS patients excite rat nociceptive visceral sensory nerves in vitro, providing new insights into the mechanism underlying visceral hypersensitivity in IBS.
Principles and standards for reporting animal experiments in The Journal of Physiology and Experimental Physiology
  • D. Grundy
  • Medicine
    Experimental physiology
  • 1 July 2015
TLDR
Detailed guidelines for how authors should report experimental procedures that involve animals are set out to facilitate the review process and decision making where there are questions regarding animal ethics.
Bladder afferent sensitivity in wild‐type and TRPV1 knockout mice
TLDR
A clear role for TRPV1 is demonstrated in the excitability of particularly low threshold bladder afferents, suggesting that TRpV1 may play an important role in normal bladder function.
Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract
TLDR
The neuroanatomy of extrinsic gastrointestinal (GI) afferent neurones, the relationship between structure and function and the role of afferents in disease are discussed, likely that they underlie diseases involving visceral hypersensitivity.
Neuroanatomy of visceral nociception: vagal and splanchnic afferent
TLDR
It is likely that vagal and splanchnic afferents play different roles in mediating sensation because of the different response profiles following activation of these pathways.
Sensory transmission in the gastrointestinal tract
TLDR
The purpose of this review is to summarize current views on sensory processing within both the enteric and extrinsic innervation and to specifically address the pharmacology of nociceptive extrinsics sensory pathways.
The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum
TLDR
It is concluded that H2S strongly inhibits in vitro intestinal and colonic motor patterns and appears to be critically dependent on K channels particularly apamin‐sensitive SK channels and glybenclamide‐sensitive K (ATP) channels.
Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract
TLDR
VR1‐like immunoreactivity was found in several locations within the GI tract and may provide sensory integration of chemical, physical, or inflammatory stimuli.
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