D. Griffin

Publications489
h-index88
Citations25,325
Highly Influential Citations792
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Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus
The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is… Expand
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β‐Chemokines MCP‐1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus–associated dementia
Human immunodeficiency virus–associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of… Expand
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Immune responses to RNA-virus infections of the CNS
  • D. Griffin
  • Biology, Medicine
  • Nature Reviews Immunology
  • 1 June 2003
A successful outcome for the host of virus infection of the central nervous system (CNS) requires the elimination of the virus without damage to essential non-renewable cells, such as neurons. As a… Expand
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Modulation of cell death by Bcl-XL through caspase interaction.
The caspases are cysteine proteases that have been implicated in the execution of programmed cell death in organisms ranging from nematodes to humans. Many members of the Bcl-2 family, including… Expand
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Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene
LITTLE is known about virus–host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the… Expand
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Localization of HIV‐1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry
Human immunodeficiency virus type 1 (HIV‐1) infects the brains of a majority of patients with the acquired immunodeficiency syndrome (AIDS), and has been linked to the development of a progressive… Expand
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Roles of Nonstructural Protein nsP2 and Alpha/Beta Interferons in Determining the Outcome of Sindbis Virus Infection
ABSTRACT Alphaviruses productively infect a variety of vertebrate and insect cell lines. In vertebrate cells, Sindbis virus redirects cellular processes to meet the needs of virus propagation. At the… Expand
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Cytokine expression in the brain during the acquired immunodeficiency syndrome
The pathogenesis of central nervous system (CNS) disease in acquired immunodeficiency syndrome (AIDS) is poorly understood but may be related to specific effects of the immune system. Cytokines such… Expand
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Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dememtia
The pathogenesis of the dementia associated with human immunodeficieny virus (HIV) infection is unclear, but has been postulated to be due to indirect effects of HIV infection including the local… Expand
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Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences.
Human immunodeficiency virus (HIV) dementia is a common clinical syndrome of uncertain pathogenesis in patients with AIDS. In several animal models of retrovirus-induced brain disease, specific viral… Expand
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