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Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis.
The high turnover of endothelial cells (EC) in atherosclerosis suggests that an increase in the frequency of both cell proliferation and cell death is important in the pathogenesis of this commonExpand
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Allograft Vasculopathy Versus Atherosclerosis
Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent toExpand
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Caspase Activation and Specific Cleavage of Substrates after Coxsackievirus B3-Induced Cytopathic Effect in HeLa Cells
ABSTRACT Coxsackievirus B3 (CVB3), an enterovirus in the familyPicornaviridae, induces cytopathic changes in cell culture systems and directly injures multiple susceptible organs and tissues in vivo,Expand
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Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
The cytotoxic granzyme B (GrB)/perforin pathway has been traditionally viewed as a primary mechanism that is used by cytotoxic lymphocytes to eliminate allogeneic, virally infected and/or transformedExpand
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Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection.
Coxsackievirus B3, a cytopathic virus in the family Picornaviridae, induces degenerative changes in host cell morphology. Here we demonstrate cytochrome c release and caspases-2, -3, -6, -7, -8, andExpand
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Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy
Photodynamic therapy (PDT) is a clinical approach that utilizes light‐activated drugs for the treatment of a variety of pathologic conditions. The initiating events of PDT‐induced apoptosis areExpand
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A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol ofExpand
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Granzyme B in injury, inflammation, and repair.
Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normalExpand
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Apoptosis: molecular aspects of cell death and disease.
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Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization
Pyropheophorbide-a methylester (PPME) is a second generation of photosensitizers used in photodynamic therapy (PDT). We demonstrated that PPME photosensitization triggered apoptosis of colon cancerExpand
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