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An infant mouse model of brain damage in pneumococcal meningitis
Bacterial meningitis due to Streptococcus pneumoniae is associated with an significant mortality rate and persisting neurologic sequelae including sensory-motor deficits, seizures, and impairments ofExpand
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Prevention of Brain Injury by the Nonbacteriolytic Antibiotic Daptomycin in Experimental Pneumococcal Meningitis
ABSTRACT Bacteriolytic antibiotics cause the release of bacterial components that augment the host inflammatory response, which in turn contributes to the pathophysiology of brain injury in bacterialExpand
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The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
Background. The brain's inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury. TheExpand
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Alphaviruses induce apoptosis in Bcl‐2‐overexpressing cells: evidence for a caspase‐mediated, proteolytic inactivation of Bcl‐2
Bcl‐2 oncogene expression plays a role in the establishment of persistent viral infection by blocking virus‐induced apoptosis. This might be achieved by preventing virus‐induced activation ofExpand
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A Tick-Borne Encephalitis Model in Infant Rats Infected With Langat Virus
Abstract Tick-borne encephalitis virus (TBEV) is the causative agent of human TBE, a severe infection that can cause long-lasting neurologic sequelae. Langat virus (LGTV), which is closely related toExpand
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Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis
Bacterial meningitis causes neuronal apoptosis in the hippocampal dentate gyrus, which is associated with learning and memory impairments after cured disease. The execution of the apoptotic programExpand
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Strategies to prevent neuronal damage in paediatric bacterial meningitis.
PURPOSE OF REVIEW The mortality of bacterial meningitis can reach 30%, and up to 50% of survivors suffer from persisting neurological deficits as a consequence of the disease. The incidence ofExpand
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Bacterial meningitis: current therapy and possible future treatment options
Despite targeted therapy, case–fatality rates and neurologic sequelae of bacterial meningitis remain unacceptably high. The poor outcome is mainly due to secondary systemic and intracranialExpand
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Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis.
Treatment of bacterial meningitis caused by Streptococcus pneumoniae is increasingly difficult, because of emerging resistance to antibiotics. Recombinant Cpl-1, a phage lysin specific for S.Expand
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Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis
BackgroundBacterial meningitis is characterized by an intense inflammatory reaction contributing to neuronal damage. The aim of this study was to obtain a comparative analysis of cytokines andExpand
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