• Publications
  • Influence
In Vivo Fate Mapping Identifies Mesenchymal Progenitor Cells
Adult mesenchymal progenitor cells have enormous potential for use in regenerative medicine. However, the true identity of the progenitors in vivo and their progeny has not been precisely defined. WeExpand
  • 147
  • 7
  • Open Access
The rational use of animal models in the evaluation of novel bone regenerative therapies.
Bone has a high potential for endogenous self-repair. However, due to population aging, human diseases with impaired bone regeneration are on the rise. Current strategies to facilitate bone healingExpand
  • 76
  • 4
  • Open Access
Increased Bone Mass Is a Part of the Generalized Lymphoproliferative Disorder Phenotype in the Mouse 12
We investigated the bone phenotype of mice with generalized lymphoproliferative disorder (gld) due to a defect in the Fas ligand-mediated apoptotic pathway. C57BL/6-gld mice had greater whole bodyExpand
  • 41
  • 4
Depletion of CD4 and CD8 T Lymphocytes in Mice In Vivo Enhances 1,25-Dihydroxyvitamin D3-Stimulated Osteoclast-Like Cell Formation In Vitro by a Mechanism That Is Dependent on Prostaglandin Synthesis1
To investigate the role of T lymphocytes in osteoclastogenesis, we performed in vivo depletion of CD4 and/or CD8 T lymphocyte subsets and evaluated in vitro osteoclast-like cell (OCL) formation. TExpand
  • 92
  • 3
Analysis of αSMA‐Labeled Progenitor Cell Commitment Identifies Notch Signaling as an Important Pathway in Fracture Healing
Fracture healing is a regenerative process that involves coordinated responses of many cell types, but characterization of the roles of specific cell populations in this process has been limited. WeExpand
  • 74
  • 3
The Fas/Fas Ligand System Inhibits Differentiation of Murine Osteoblasts but Has a Limited Role in Osteoblast and Osteoclast Apoptosis1
Apoptosis through Fas/Fas ligand (FasL) is an important regulator of immune system homeostasis but its role in bone homeostasis is elusive. We systematically analyzed: 1) the expression of Fas/FasLExpand
  • 37
  • 3
Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood
The in vivo origin of bone‐producing osteoblasts is not fully defined. Skeletal stem cells, a population of mesenchymal stem cells resident in the bone marrow compartment, are thought to act asExpand
  • 65
  • 2
Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine.
This study addressed the role of impairment of osteoblastic differentiation as a mechanism underlying pathophysiology of the osteogenesis imperfecta (OI). We hypothesized that combination of impairedExpand
  • 47
  • 2
Medicinska fiziologija - udžbenik
  • 4
  • 2
Genetic variability of new bone induction in mice.
We studied differences in ectopic osteoinduction in eight mouse inbred strains and an outbred strain. Antigen-extracted autolyzed rat bone gelatin was implanted under hind limb muscle fascia ofExpand
  • 44
  • 1