• Publications
  • Influence
Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum
TLDR
The receptors for P. falciparum GPI-induced cell signaling that leads to proinflammatory responses are identified, and the GPI structure-activity relationship is studied, implying that macrophage surface phospholipases play important roles in the G PI-induced innate immune responses and malaria pathogenesis. Expand
Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum
TLDR
This study demonstrates that the parasite GPIs can effectively induce the production of TNF-α at 5-20 nm concentrations in interferon-γ-primed monocytes and macrophages and investigates the requirement of the extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and NF-κB-signaling pathways that are activated in response to P. falciparum GPI stimuli. Expand
Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis.
TLDR
Absence of a persistent anti- GPI antibody response correlated with malaria-specific anemia and fever, suggesting that anti-GPI antibodies provide protection against clinical malaria. Expand
Protein–DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses
TLDR
The results demonstrate that a protein–DNA complex is the exclusive parasite component that activates DCs by a TLR9-dependent pathway to produce inflammatory cytokines, and contribute substantially toward the understanding of malaria parasite-recognition mechanisms. Expand
CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria1
TLDR
It is shown that selective engagement and internalization of this receptor did not lead to proinflammatory cytokine production by primary human and murine macrophages, and that CD36 must cooperate with other receptors such as TLRs to participate in cytokine responses. Expand
The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL
TLDR
It is demonstrated that soluble glycophorin C completely blocks the binding of BAEBL (VSTK) to human erythrocytes, and it is suggested that single-point mutations in BaeBL allow P. falciparum to recognize oligosaccharides on different ery Throthrocyte surface glycoproteins or glycolipids, greatly increasing its invasion range. Expand
Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A
TLDR
The structure of the CSA binding DBL3x domain is described, a Duffy binding-like (DBL) domain of VAR2CSA of P. falciparum–infected erythrocytes that is identified to be a cluster of conserved positively charged residues on subdomain 2 and subdomain 3. Expand
Disruption of CD36 Impairs Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol and Confers Susceptibility to Severe and Fatal Malaria In Vivo1
TLDR
Results provide direct evidence that pfGPI induces TNF-α secretion in a CD36-dependent manner and support a role for CD36 in modulating host cytokine response and innate control of acute blood-stage malaria infection in vivo. Expand
Gravidity-Dependent Production of Antibodies That Inhibit Binding of Plasmodium falciparum-Infected Erythrocytes to Placental Chondroitin Sulfate Proteoglycan during Pregnancy
ABSTRACT During pregnancy, Plasmodium falciparum-infected erythrocytes sequester in the placenta by adhering to chondroitin 4-sulfate, creating a risk factor for both the mother and the fetus. TheExpand
Glycosylphosphatidylinositol Anchors Represent the Major Carbohydrate Modification in Proteins of Intraerythrocytic Stage Plasmodium falciparum*
TLDR
The results established the following: 1) glycosylphosphatidylinositol (GPI) anchors represent the major carbohydrate modification in the intraerythrocytic stage P. falciparum proteins; 2) in contrast to previous reports, O-linked carbohydrates are either absent or present only at very low levels in the parasite; and 3) P. Falcon contains low levels of N-glycosylation capability. Expand
...
1
2
3
4
5
...