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PHARMACOKINETICS AND TISSUE RESIDUES OF TELAZOL® IN FREE-RANGING POLAR BEARS
TLDR
It was concluded that during immobilization, both tiletamine and zolazepam levels decline rapidly in a monoexponential fashion, and their pharmacokinetic parameters in polar bears are similar to those observed in other species. Expand
Chloral hydrate disposition following single-dose administration to critically ill neonates and children.
TLDR
A highly significant negative correlation was observed amongst the three groups for the half-life (t1/2) and area-under-the-curve for 0 to infinity values for trichloroethanol (TCE), the active metabolite responsible for the sedation effect. Expand
3,5‐Bis(benzylidene)‐4‐oxo‐1‐phosphonopiperidines and Related Diethyl Esters: Potent Cytotoxins with Multi‐Drug‐Resistance Reverting Properties
TLDR
The N‐phosphono compounds 5, which are more hydrophilic than the analogues in series 3 and 4, were the most potent cluster of cytotoxins, and, in particular, 3,5‐bis‐(2‐nitrobenzylidene)‐1‐ phosphono‐4‐piperidone 5 g had an average IC50 value of 34 nM toward the two T‐lymphocyte cell lines. Expand
Novel 3,5-bis(arylidene)-4-piperidone dimers: potent cytotoxins against colon cancer cells.
TLDR
Two novel series of dimeric 3,5-bis(arylidene)-4-piperidones 7 and 8 were prepared as cytotoxic agents and Flow cytometry analysis of a representative potent compound 7f revealed that it induces apoptosis in HCT116 cells. Expand
Sedative/hypnotic effects of chloral hydrate in the neonate: trichloroethanol or parent drug?
TLDR
Based on the results of the present study, the sedative/hypnotic effects of TCE cannot be ruled out completely but in the neonate, the parent drug CH seems to have a more important role than has been previously suggested from human research. Expand
Chloral hydrate sedation in neonates and infants--clinical and pharmacologic considerations.
TLDR
Multiple dosing of chloral hydrate in preterm infants should be used with caution and frequent monitoring of serum bilirubin concentrations is indicated in such cases. Expand
Oscillatory potentials and light microscopic changes demonstrate an interaction between zinc and taurine in the developing rat retina.
TLDR
Evidence is provided for an interaction between zinc and taurine in retinal morphology and function and photoreceptor degeneration and confirmed retinal dysplasia in rats deficient in both zinc andTaurine. Expand
Bis[3,5‐bis(benzylidene)‐4‐oxo‐1‐piperidinyl]amides: A Novel Class of Potent Cytotoxins
TLDR
The hypothesis that doubling the number of sites available for thiol alkylation in a series of candidate cytotoxins increases potency more than two‐fold was tested and molecular modeling revealed that relative locations of the amidic groups correlate with cytotoxicity. Expand
Chloral hydrate sedation in neonates and infants--clinical and pharmacologic considerations.
TLDR
Multiple dosing of chloral hydrate in preterm infants should be used with caution and frequent monitoring of serum bilirubin concentrations is indicated in such cases. Expand
Evidence-based evaluation of potential benefits and safety of beta-alanine supplementation for military personnel.
TLDR
The strength of evidence in terms of the potential for risk of bias in the quality of the available literature, consistency, directness, and precision did not support the use of beta-alanine by military personnel. Expand
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