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Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions.
Paradoxical fate and biological action of peroxynitrite on human platelets.
- M. A. Moro, V. Darley-Usmar, S. Moncada
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 5 July 1994
The fate and therefore the actions of ONOO- in biological systems are critically dependent on the biological environment in which this oxidant is present.
Development and Validation of the Pediatric Oncology Quality of Life Scale
Development of a 21-item, parent report measure for assessing the quality of life (QOL) of children with cancer demonstrated good concurrent and discriminant relationships with scores on measures of adjustment hypothesized to covary with the dimensions of QOL assessed.
Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve
Signaling from Blood Vessels to CNS Axons through Nitric Oxide
It is found from experiments on a rodent central white matter tract (the optic nerve) in vitro that microvascular endothelial cells signal persistently to axons using nitric oxide derived from the endothelial NO synthase (eNOS) to participate in signal processing in the brain.
HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.
The genetic diversity of HIV-1 represents a major challenge in vaccine development. In this study, we establish a rationale for eliminating HIV-1-infected cells by targeting cellular immune responses…
Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses.
- T. Bellamy, J. Wood, D. Goodwin, J. Garthwaite
- BiologyProceedings of the National Academy of Sciences…
- 14 March 2000
A major receptor for nitric oxide (NO) is the cGMP-synthesizing enzyme, soluble guanylyl cyclase (sGC), but it is not known how this enzyme behaves in cells. In cerebellar cells, NO (from…
Mechanisms of ischaemic damage to central white matter axons: a quantitative histological analysis using rat optic nerve
Pharmacokinetics and antibodies.
- D. Goodwin
- BiologyJournal of nuclear medicine : official…
- 1 August 1987
Antibodies against metal chelates
These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude, which introduces a new degree of control over the biological distributions of chelated radionuclides.