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Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial.
CONTEXT The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome isExpand
  • 1,108
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Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial.
CONTEXT Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue. OBJECTIVE To determine theExpand
  • 1,417
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Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress
Background—Circulating levels of interleukin-6 (IL-6) and tumor necrosis factor-&agr; (TNF-&agr;) are elevated in diabetic patients. We assessed the role of glucose in the regulation of circulatingExpand
  • 1,515
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Oxidative Stress and Diabetic Vascular Complications
Long-term vascular complications still represent the main cause of morbidity and mortality in diabetic patients. Although prospective randomized long-term clinical studies comparing the effects ofExpand
  • 1,900
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Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.
OBJECTIVES To compare the effect of a high-fat meal and a high-carbohydrate meal (pizza), with and without antioxidant vitamins, on endothelial activation in healthy subjects and in patients withExpand
  • 527
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The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals.
OBJECTIVES The aim of this study was to meta-analyze epidemiological studies and clinical trials that have assessed the effect of a Mediterranean diet on metabolic syndrome (MS) as well as itsExpand
  • 727
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Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year
Background—Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response. Methods and Results—Fifty-six healthyExpand
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Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial.
ContextThe metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome isExpand
  • 892
  • 19
Effects of a Mediterranean-Style Diet on the Need for Antihyperglycemic Drug Therapy in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Trial
Patients with newly diagnosed type 2 diabetes are usually managed by pharmacotherapy as well as lifestyle changes. The latter are often ineffective and pharmacotherapy may fail over time or mayExpand
  • 163
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Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial.
CONTEXT Healthy lifestyle factors are associated with maintenance of erectile function in men. OBJECTIVE To determine the effect of weight loss and increased physical activity on erectile andExpand
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