Author pages are created from data sourced from our academic publisher partnerships and public sources.
Function and Regulation of CREB Family Transcription Factors in the Nervous System
CREB and its close relatives are now widely accepted as prototypical stimulus-inducible transcription factors. In many cell types, these factors function as effector molecules that bring about… Expand
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
A signaling pathway has been elucidated whereby growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of… Expand
Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.
Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generated… Expand
Neuropilin Is a Semaphorin III Receptor
- A. Kolodkin, Dorothy V Levengood, Erica G Rowe, Y. Tai, R. Giger, D. Ginty
- Medicine, Biology
- 22 August 1997
The semaphorin family contains a large number of phylogenetically conserved proteins and includes several members that have been shown to function in repulsive axon guidance. Semaphorin III (Sema… Expand
A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos
- S. Ahn, M. Olive, S. Aggarwal, D. Krylov, D. Ginty, C. Vinson
- Medicine, Biology
- Molecular and Cellular Biology
- 1 February 1998
ABSTRACT Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for… Expand
The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling… Expand
Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning… Expand
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
Mammalian circadian rhythms are regulated by a pacemaker within the suprachiasmatic nuclei (SCN) of the hypothalamus. The molecular mechanisms controlling the synchronization of the circadian… Expand
The Sensory Neurons of Touch
The somatosensory system decodes a wide range of tactile stimuli and thus endows us with a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback and social… Expand
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
Calcium ions (Ca2+) act as an intracellular second messenger and can enter neurons through various ion channels. Influx of Ca2+ through distinct types of Ca2+ channels may differentially activate… Expand