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- Publications
- Influence
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
- J. Huh, M. Leung, +14 authors D. Littman
- Biology, Medicine
- Nature
- 28 April 2011
CD4+ T helper lymphocytes that express interleukin-17 (TH17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes… Expand
Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
- G. Ragupathi, J. R. Gardner, P. Livingston, D. Gin
- Biology, Medicine
- Expert review of vaccines
- 1 April 2011
One of the most widely used and potent immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria). Despite challenges in production,… Expand
Cell-selective labeling with amino acid precursors for proteomic studies of multicellular environments
- N. P. Gauthier, Boumediene Soufi, +6 authors Martin L. Miller
- Biology, Medicine
- Nature Methods
- 30 June 2013
We report a technique to selectively and continuously label the proteomes of individual cell types in coculture, named cell type–specific labeling using amino acid precursors (CTAP). Through… Expand
Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
- Danica P. Galonić, D. Gin
- Biology, Medicine
- Nature
- 26 April 2007
Therapeutic vaccines derived from carbohydrate antigen–adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient… Expand
Synthesis of the potent immunostimulatory adjuvant QS-21A.
- P. Wang, Yong-Jae Kim, Mauricio Navarro-Villalobos, Bridget D. Rohde, D. Gin
- Chemistry, Medicine
- Journal of the American Chemical Society
- 18 February 2005
QS-21A is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy, given its exceedingly high level of potency and its favorable toxicity profile.… Expand
Development of a minimal saponin vaccine adjuvant based on QS-21
- Alberto Fernández-Tejada, Eric K. Chea, +7 authors D. Gin
- Chemistry, Medicine
- Nature chemistry
- 1 June 2014
Adjuvants are materials added to vaccines to enhance the immunological response to an antigen. QS-21 is a natural product adjuvant under investigation in numerous vaccine clinical trials, but its use… Expand
Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification.
- Danica P. Galonić, N. Ide, W. A. van der Donk, D. Gin
- Chemistry, Medicine
- Journal of the American Chemical Society
- 3 May 2005
The development of a method for site- and stereoselective peptide modification using aziridine-2-carboxylic acid-containing peptides is described. A solid-phase peptide synthesis methodology that… Expand
Synthetic Studies of the Tunicamycin Antibiotics. Preparation of (+)-Tunicaminyluracil, (+)-Tunicamycin-V, and 5'-epi-Tunicamycin-V
- A. Myers, D. Gin, D. H. Rogers
- Chemistry
- 1 June 1994
DEHYDRATIVE GLYCOSYLATION WITH 1-HYDROXY DONORS
- D. Gin
- Chemistry
- 31 December 2002
The preparation of complex carbohydrates has emerged as a major focus in synthetic organic chemistry, and this is no doubt a result of the growing awareness of the many important roles of this class… Expand