• Publications
  • Influence
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (TH17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processesExpand
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Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
One of the most widely used and potent immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria). Despite challenges in production,Expand
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Cell-selective labeling with amino acid precursors for proteomic studies of multicellular environments
We report a technique to selectively and continuously label the proteomes of individual cell types in coculture, named cell type–specific labeling using amino acid precursors (CTAP). ThroughExpand
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Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
Therapeutic vaccines derived from carbohydrate antigen–adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficientExpand
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Synthesis of the potent immunostimulatory adjuvant QS-21A.
QS-21A is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy, given its exceedingly high level of potency and its favorable toxicity profile.Expand
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Development of a minimal saponin vaccine adjuvant based on QS-21
Adjuvants are materials added to vaccines to enhance the immunological response to an antigen. QS-21 is a natural product adjuvant under investigation in numerous vaccine clinical trials, but its useExpand
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Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification.
The development of a method for site- and stereoselective peptide modification using aziridine-2-carboxylic acid-containing peptides is described. A solid-phase peptide synthesis methodology thatExpand
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  • D. Gin
  • Chemistry
  • 31 December 2002
The preparation of complex carbohydrates has emerged as a major focus in synthetic organic chemistry, and this is no doubt a result of the growing awareness of the many important roles of this classExpand
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