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The role of endothelins and their receptors in heart failure.
Endothelin (ET) is a peptide composed of 21 amino acids, derived from a larger precursor, the big-endothelin, by action of the endothelin-converting enzyme (ECE) family; three isoforms of endothelin,Expand
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C‐type natriuretic peptide plasma levels increase in patients with chronic heart failure as a function of clinical severity
C‐type natriuretic peptide (CNP), secreted by the endothelium and the heart, is structurally related to atrial and brain natriuretic peptides, but its clinical significance in chronic heart failureExpand
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Antiplatelet activity of synthetic and natural resveratrol in red wine.
The antiaggregating effect of the phytoalexin resveratrol (3,4,5-trihydroxystilbene), alone or associated with red wine, and polyphenol have been evaluated in vitro at different concentrations onExpand
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Detection of Significant Coronary Artery Disease by Noninvasive Anatomical and Functional Imaging
Background—The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparativeExpand
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Comparison of NT-proCNP and CNP plasma levels in heart failure, diabetes and cirrhosis patients
C-type natriuretic peptide (CNP) plasma levels are extremely low and a pre-analytical phase is necessary to assay plasma CNP concentrations. Amino-terminal CNP (NT-proCNP) circulates at higherExpand
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Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart
C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, inExpand
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Tissue-specific selection of stable reference genes for real-time PCR normalization in an obese rat model.
Obesity is a complex pathology with interacting and confounding causes due to the environment, hormonal signaling patterns, and genetic predisposition. At present, the Zucker rat is an eligibleExpand
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Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid.
In this work a novel self-powered microneedle-based transdermal biosensor for pain-free high-accuracy real-time measurement of glycaemia in interstitial fluid (ISF) is reported. The proposedExpand
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Selection of reference genes for normalization of real-time PCR data in minipig heart failure model and evaluation of TNF-α mRNA expression.
Real-time PCR is the benchmark method for measuring mRNA expression levels, but the accuracy and reproducibility of its data greatly depend on appropriate normalization strategies. Though the minipigExpand
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HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain.
OBJECTIVES Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identifyExpand
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