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The biology of cancer invasion and metastasis.
Publisher Summary This chapter summarizes the findings and hypotheses of cancer metastasis and elucidates the complex mechanisms involved in the pathogenesis of metastasis. The development of a… Expand
Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.
This report describes the selection and behavior of tumor cells resistant to cytolysis by syngeneic lymphocytes. Two B16 melanoma lines, F1 (low metastasis) and F10 (high metastasis), were cultured… Expand
Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis
The kinetics of initial arrest in organs, distribution, survival, and fate of 125Iiododeoxyuridine‐labeled B16 melanoma tumor cells injected intravenously into normal, tumor‐sensitized and immune… Expand
Biochemical Parameters correlated with Tumour Cell Implantation
FIDLER1 has described melanoma cell lines produced by serial injection into and collection from C57 mice, some lines of which produce few pulmonary metastases while others have greatly increased… Expand
Influence of immune status on the metastasis of three murine fibrosarcomas of different immunogenicities.
Three fibrosarcomas of different immunogenicities were tested for their ability to form spontaneous and experimentally induced metastases in normal, sham-suppressed, immunosuppressed, and… Expand
Novel Experimental Approaches to Melanoma Diagnosis and Therapy
We have investigated the potential use of immune therapies on the growth of melanoma metastases in a new animal model that more closely approximates the clinical situation. We have found that… Expand
A rapid, novel method for the solid-phase derivatization of IgG antibodies for immune-affinity chromatography.
We show that a solid-phase immune adsorbent can be prepared from rabbit antiserum by isolating the IgG fraction with the A protein of Staphylococcus aureus associated covalently with a Sepharose… Expand
Demonstration and isolation of murine melanoma-associated antigenic surface proteins.
Abstract Melanomas are antigenic and induce the formation of antibodies in both syngeneic and xenogeneic species. The nature of melanoma-associated antigens remains problematic, however. We found… Expand
Amino-terminal variation in melanoma antigens.
- J. Marchalonis, C. Schwabe, D. Gersten, V. Hearing
- Biology, Medicine
- Biochemical and biophysical research…
- 31 May 1984
Melanoma tumors express both common antigenic determinants and individually specific markers. A melanoma-specific glycoprotein antigen ( B700 ) with a molecular weight of approximately 65,000 daltons… Expand
Murine melanoma-specific tumor rejection activity elicited by a purified, melanoma-associated antigen.
- V. Hearing, D. Gersten, P. Montague, W. Vieira, G. Galetto, L. Law
- Biology, Medicine
- Journal of immunology
- 1 July 1986
B700 is a melanoma-specific glycoprotein antigen, with a m.w. of 65,000 and an isoelectric point of 4.5; this antigen has been shown to bear significant sequence homology to a normally occurring… Expand