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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72. This polymorphism occurs in the proline-rich domain of p53, whichExpand
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Amplification of a gene encoding a p53-associated protein in human sarcomas
DESPITE extensive data linking mutations in the p53 gene to human tumorigenesis1, little is known about the cellular regulators and mediators of p53 function. MDM2 is a strong candidate for one suchExpand
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Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex
The tumour suppressor activity of the p53 protein has been explained by its ability to induce apoptosis in response to a variety of cellular stresses. Thus, understanding the mechanism by which p53Expand
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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.
There is growing evidence that the p53 tumor suppressor protein not only can function to activate gene transcription but also to repress the expression of specific genes. Although recent studies haveExpand
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A small molecule inhibitor of inducible heat shock protein 70.
The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70 expression is elevated in many cancers,Expand
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Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein*
The MDM2 oncoprotein has transforming potential that can be activated by overexpression, and it represents a critical regulator of the p53 tumor suppressor protein. To identify other factors with aExpand
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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
We have carried out an analysis of amplified DNA sequences present in a tumorigenic mouse cell line, designated 3T3DM, to determine if the presence of cellular transforming activity is correlatedExpand
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Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.
The p53 tumor suppressor gene product can complex with polypeptides encoded by the mdm2 putative protoncogene. In addition, mdm2 mRNA levels have been shown to increase following the activation ofExpand
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HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells
The evolutionarily conserved stress-inducible HSP70 molecular chaperone plays a central role in maintaining protein quality control in response to various forms of stress. Constitutively elevatedExpand
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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.
A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 exists in African-descent populations (P47S, rs1800371; referred to here as S47). Here we report that, in human cell lines and aExpand
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