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Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390
TLDR
The different regional and laminar distributions of D1 and D2 dopaminergic receptors indicates that they may subserve different aspects of dopamine function in the cerebral cortex. Expand
Autoradiographic Localization of CRF1 and CRF2 Binding Sites in Adult Rat Brain
TLDR
Autoradiographic findings provide evidence that each subtype has a distinct regional distribution, thus strengthening the suggestion that CRF1 and CRF2 receptors serve different roles in mediating CRF function. Expand
Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity
TLDR
Electrophysiological evidence for decreased postsynaptic sensitivity to GABA following chronic benzodiazepine administration is presented as measured by the direct iontophoretic application of GABA and serotonin onto serotonergic cells in the midbrain dorsal raphe nucleus (DRN), known to receive GABAergic input. Expand
Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex
TLDR
The findings reveal that visual cortical areas differ in density and lamination of neurotransmitter receptors and presumably in their sensitivity to circulating levels of endogenous neurotransmitters and pharmacologically active compounds. Expand
Receptors for the age of anxiety: pharmacology of the benzodiazepines.
TLDR
Evidence indicates that the benzodiazepines exert their therapeutic effects by interacting with a high-affinity binding site (receptor) in the brain and several naturally occurring compounds, including the purines and nicotinamide, are candidates for this role. Expand
Continuous release of diazepam: Electrophysiological, biochemical and behavioral consequences
TLDR
Since the decrease in GABAergic responsiveness was observed in the presence of measurable levels of diazepam, it was concluded that this subsensitivity phenomenon is associated with tolerance and not with withdrawal effects of the benzodiazepines. Expand
Quantitative autoradiographic mapping of serotonin 5‐HT1 and 5‐HT2 receptors and uptake sites in the neocortex of the rhesus monkey
TLDR
The complementary patterns of distribution of 5‐HT1 and 5‐ HT2 receptors in most areas of the monkey cerebral cortex suggest that these two receptor subtypes may make differential contributions to cortical functions. Expand
Allosteric uncoupling after chronic benzodiazepine exposure of recombinant gamma-aminobutyric acid(A) receptors expressed in Sf9 cells: ligand efficacy and subtype selectivity.
TLDR
The present study shows that drug efficacy plays a critical role in determining the degree of uncoupling, and perhaps, in the development of tolerance and dependence, and suggests that alterations at the GABA(A) receptor complex after chronic benzodiazepine exposure are mediated directly by agonist effects at theiazepine receptor complex. Expand
The GABA-ergic system: a locus of benzodiazepine action.
TLDR
How interaction of binding sites for GABA, benzodiazepines (BDZ) , andBDZ is described describes how these compounds are capable of producing a spectrum of activities depends on the mode of interaction. Expand
Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase
TLDR
Using a retrograde tracer technique with microiontophoretically applied horseradish peroxidase (HRP), afferent projections to the brain stem raphe nuclei and to two adjacent reticular nuclei, nucleus reticularis pontis caudalis (nRPC) and nucleus gigantocellularis (nGC) were identified. Expand
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