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Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution
Differential effects of early hippocampal pathology on episodic and semantic memory.
- F. Vargha-Khadem, D. Gadian, K. Watkins, A. Connelly, W. van Paesschen, M. Mishkin
- Psychology, BiologyScience
- 18 July 1997
Global anterograde amnesia is described in three patients with brain injuries that occurred in one case at birth, in another by age 4, and in the third at age 9. Magnetic resonance techniques…
Delay and dispersion effects in dynamic susceptibility contrast MRI: Simulations using singular value decomposition
Both delay and dispersion were found to introduce significant underestimation of cerebral blood flow (CBF) and overestimation of mean transit time (MTT) in DSC quantification.
Hippocampal Volume and Everyday Memory in Children of Very Low Birth Weight
The preterm group had significantly smaller hippocampal volumes bilaterally, despite equivalent head size, and showed specific deficits in certain aspects of everyday memory, both on objective testing and as indicated by parental questionnaires.
NMR and its Applications to Living Systems
- D. Gadian
- Chemistry, Biology
- 22 February 1996
Theoretical basis of NMR, MRS and tissue biochemistry, instrument design and operation, and Pulse sequences Index.
Developmental amnesia associated with early hypoxic-ischaemic injury.
- D. Gadian, J. Aicardi, K. Watkins, D. Porter, M. Mishkin, F. Vargha-Khadem
- Psychology, BiologyBrain : a journal of neurology
- 1 March 2000
It is suggested that the degree of hypoxia-ischaemia was sufficient to produce selective damage to particularly vulnerable regions of the brain, notably the hippocampi, but was not sufficient to result in the more severe neurological and cognitive deficits that can follow hypoxic- ischaemic injury.
Neural basis of an inherited speech and language disorder.
- F. Vargha-Khadem, K. Watkins, R. Passingham
- BiologyProceedings of the National Academy of Sciences…
- 13 October 1998
The genetic mutation or deletion in this region has resulted in the abnormal development of several brain areas that appear to be critical for both orofacial movements and sequential articulation, leading to marked disruption of speech and expressive language.
Language fMRI abnormalities associated with FOXP2 gene mutation
- F. Liégeois, T. Baldeweg, A. Connelly, D. Gadian, M. Mishkin, F. Vargha-Khadem
- Psychology, BiologyNature Neuroscience
- 12 October 2003
The affected members of the KE family showed significant underactivation relative to the unaffected members in Broca's area and its right homolog, as well as in other cortical language-related regions and in the putamen.
Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study.
It is difficult to infer intra- versus inter-hemispheric language reorganization on the basis of clinical observations in the presence of early pathology to the left hemisphere, and handedness, age at onset of chronic seizures, and site of EEG abnormality also showed no obvious association with language lateralization.
FOXP2 and the neuroanatomy of speech and language
The discovery of a mutation in FOXP2 in a family with a speech and language disorder has enabled neuroscientists to trace the neural expression of this gene during embryological development, track the effects ofThis gene mutation on brain structure and function, and so begin to decipher that part of the authors' neural inheritance that culminates in articulate speech.