• Publications
  • Influence
Production of eosinophil chemoattractant activity by ovine gastrointestinal nematodes.
Eosinophilia is a well documented feature of helminth infections but the precise nature of the interaction between parasite and eosinophil remains an enigma. This paper describes experimentsExpand
  • 31
  • 2
Characterization of a galectin-like activity from the parasitic nematode, Haemonchus contortus, which modulates ovine eosinophil migration in vitro.
The development of eosinophilia is a characteristic feature of helminth infection, although the exact nature of the interaction between eosinophils and parasites remains to be fully defined.Expand
  • 46
  • 1
TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis
BackgroundExperimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4+ T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population thatExpand
  • 18
  • 1
  • PDF
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors
Foxp3+ regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enrichedExpand
  • 11
  • 1
  • PDF
Cutting Edge: IL-6–Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, Source
Mice lacking IL-6 are resistant to autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE), which is driven by CNS-reactive CD4+ T cells. There are multiple cellular sources ofExpand
  • 39
T-bet Expression by Foxp3+ T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis
Accumulation of T regulatory (Treg) cells within the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) is essential for the resolution of disease. CNS Treg cellsExpand
  • 29
  • PDF
Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells
Interest in manipulating the immunosuppressive powers of Foxp3‐expressing T regulatory cells as an immunotherapy has been tempered by their reported ability to produce proinflammatory cytokines whenExpand
  • 5
  • PDF
Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System.
Experimental autoimmune encephalomyelitis (EAE) is an animal model commonly used to investigate the inflammatory response in organ-specific autoimmunity and a model of the early immune responses ofExpand
  • 1
IL-6-dependent autoimmune disease: dendritic cells as a sufficient, but transient, source1
Mice lacking IL-6 are resistant to autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE), which is driven by central nervous system (CNS)-reactive CD4+ T cells. There areExpand
  • 1
  • PDF
Abstract 3877: MPL-5821, a macrophage targeted ESMTM p38 MAPK inhibitor, inhibits the production of TLR agonist induced IL-10 whilst sparing T-cell functionality
Compensatory release of immunosuppressive cytokines, such as IL-10, by macrophages present in the tumor microenvironment has been implicated as a mechanism for adaptive resistance to a number ofExpand
  • 1