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Anticancer Agents from Natural Products
Introduction Gordon M. Cragg, David G. I. Kingston, and David J. Newman Camptothecin and Its Analogs Nicolas J. Rahier, Craig J. Thomas, and Sidney M. Hecht The Discovery and Development of theExpand
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Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor‐targeted drug delivery vectors
Nanotechnology applied to biological problems represents an emerging field with the potential for the development of exquisitely sensitive diagnostics and targeted cancer therapies. Expand
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Kaurane and trachylobane diterpenes from Xylopia aethiopica
Abstract Phytochemical investigation of Xylopia aethiopica (Annonaceae) has resulted in the isolation of two novel diterpenes, 15-oxo-(-)-trachyloban-19-oic acid and (-)-kaur-15-en-17-al-19-oic acid.Expand
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Taxol®: science and applications.
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The Taxane Diterpenoids
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Identification of the structural region of taxol that may be responsible for cytokine gene induction and cytotoxicity in human ovarian cancer cells
Purpose: Interleukin-8 (IL-8) is a pleiotropic chemokine with both chemoattractant and angiogenic properties. In addition to its cytotoxic effects on ovarian cancer cells, taxol can transcriptionallyExpand
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Recent Advances in the Chemistry of Taxol1,2
The history of the development of the important anticancer drug taxol (1) is briefly described, and recent studies of its chemistry and tubulin-binding conformation are then presented. TopicsExpand
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Taxol, a molecule for all seasons
The diterpenoid natural product taxol, first discovered in the 1960’s has proved to be the most important new anticancer drug introduced in the last ten years. A brief history of taxol’s Expand
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