• Publications
  • Influence
Juvenile xanthogranuloma: forms of systemic disease and their clinical implications.
OBJECTIVE Juvenile xanthogranuloma (JXG) with systemic (extracutaneous) involvement is a rare histiocytic disorder in which significant morbidity and occasional deaths may occur. The objective ofExpand
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Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale.
PURPOSE The platinum chemotherapy agents cisplatin and carboplatin are widely used in the treatment of adult and pediatric cancers. Cisplatin causes hearing loss in at least 60% of pediatricExpand
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Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.
PURPOSE Surgery is curative therapy for pediatric low-grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas where complete resection is notExpand
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Care of the dying adolescent: special considerations.
More than 3000 adolescents in the United States die annually from the effects of chronic illness. Providing appropriate end-of-life care for these patients is particularly challenging because ofExpand
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Clinical outcomes after long-term treatment with alglucosidase alfa in infants and children with advanced Pompe disease
Purpose: A clinical trial was conducted to evaluate the safety and efficacy of alglucosidase alfa in infants and children with advanced Pompe disease.Methods: Open-label, multicenter study of IVExpand
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Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches.
  • D. Freyer
  • Medicine
  • Journal of clinical oncology : official journal…
  • 10 November 2010
PURPOSE Young adult survivors of childhood and adolescent cancer are an ever-growing population of patients, many of whom remain at lifelong risk for potentially serious complications of their cancerExpand
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Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Longer and more intensive postinduction intensification (PII) improved the outcome of children and adolescents with "higher risk" acute lymphoblastic leukemia (ALL) and a slow marrow response toExpand
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Pleuropulmonary blastoma: a marker for familial disease.
OBJECTIVE To catalog and evaluate patterns of disease in families of children with pleuropulmonary blastoma (PPB). METHODS Data have been collected since 1988 on 45 children with PPB and theirExpand
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Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group.
PURPOSE Previous studies regarding the influence of weight on event-free survival (EFS) and treatment-related toxicity (TRT) in childhood acute lymphoblastic leukemia (ALL) considered only weight atExpand
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Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients
Studies comparing survival of adolescent and young adult (AYA) patients to that of younger patients with newly diagnosed acute myeloid leukemia (AML) have yielded conflicting results. In order toExpand
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