Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.
- N. Volkow, L. Chang, +10 authors N. Pappas
- Psychology, Medicine
- The American journal of psychiatry
- 1 December 2001
OBJECTIVE
The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine… Expand
Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence
- N. Volkow, L. Chang, +8 authors J. Logan
- Psychology, Medicine
- The Journal of Neuroscience
- 1 December 2001
Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant… Expand
Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.
- N. Volkow, L. Chang, +10 authors E. Miller
- Psychology, Medicine
- The American journal of psychiatry
- 1 March 2001
OBJECTIVE
Methamphetamine is a popular and highly addictive drug of abuse that has raised concerns because it has been shown in laboratory animals to be neurotoxic to dopamine terminals. The authors… Expand
Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain
- N. Volkow, G. Wang, +7 authors D. Franceschi
- Psychology, Medicine
- The Journal of Neuroscience
- 15 January 2001
Methylphenidate (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of attention deficit hyperactivity disorder (ADHD), yet the mechanisms responsible for its… Expand
Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers.
- N. Volkow, L. Chang, +8 authors J. Logan
- Psychology, Medicine
- The American journal of psychiatry
- 1 March 2001
OBJECTIVE
Methamphetamine has raised concerns because it may be neurotoxic to the human brain. Although prior work has focused primarily on the effects of methamphetamine on dopamine cells, there is… Expand
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
The drive for food is one of the most powerful of human and animal behaviors. Dopamine, a neurotransmitter involved with motivation and reward, its believed to regulate food intake in laboratory… Expand
Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications
- N. Volkow, G. Wang, +8 authors J. Swanson
- Psychology, Medicine
- Synapse
- 1 March 2002
Methylphenidate (Ritalin) is an effective drug in the treatment of attention deficit hyperactivity disorder. However, the doses required therapeutically vary significantly between subjects and it is… Expand
Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain.
The route of administration influences the reinforcing effects of cocaine. Here we assessed whether there were differences in the efficacy of cocaine to block the dopamine transporters (major target… Expand
Low doses of alcohol substantially decrease glucose metabolism in the human brain
TLDR
Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
Though the blockade of dopamine transporters (DAT) is associated with cocaine's and methylphenidate's reinforcing effects, it is the stimulation of dopamine (DA) receptors, achieved by increases in… Expand