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Lead and Calcium Produce Rod Photoreceptor Cell Apoptosis by Opening the Mitochondrial Permeability Transition Pore*
Calcium overload is suggested to play a fundamental role in the process of rod apoptosis in chemical-induced and inherited retinal degenerations. However, this hypothesis has not been testedExpand
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Oxygen consumption in the rat outer and inner retina: light- and pharmacologically-induced inhibition.
Biochemical, physiological and histological data have established that 55-65% of retinal mitochondria are located in the photoreceptor inner segments and suggested that photoreceptors have at least aExpand
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The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases
Purpose The homeostatic regulation of cellular ATP is achieved by the coordinated activity of ATP utilization, synthesis, and buffering. Glucose is the major substrate for ATP synthesis throughExpand
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Calcium Overload Triggers Rod Photoreceptor Apoptotic Cell Death in Chemical‐Induced and Inherited Retinal Degenerations
Impairment and loss of vision are major human health problems. The majority of these cases have a retinal origin.1 For example, selective rod photoreceptor cell apoptosis occurs in humans and animalsExpand
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Low-Level Human Equivalent Gestational Lead Exposure Produces Sex-Specific Motor and Coordination Abnormalities and Late-Onset Obesity in Year-Old Mice
Background Low-level developmental lead exposure is linked to cognitive and neurological disorders in children. However, the long-term effects of gestational lead exposure (GLE) have received littleExpand
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Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
  • L. He, G. Perkins, +4 authors D. Fox
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 January 2003
Photoreceptor apoptosis and resultant visual deficits occur in humans and animals with inherited and disease-, injury-, and chemical-induced retinal degeneration. A clinically relevant mouse model ofExpand
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Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications.
PURPOSE Comparative studies of structure related to function offer a promising means of understanding the significance of differences in cytoarchitecture. Mitochondrial crista structure is linkedExpand
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Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies.
To date, only a small number of commercial chemicals have been tested and documented as developmental neurotoxicants. Moreover, an increasing number of epidemiological, clinical and experimentalExpand
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Heavy metals affect rod, but not cone, photoreceptors.
Low concentrations of lead, mercury, or cadmium depress the amplitude of the rod receptor potential in the perfused bullfrog retina. Responses from the cones were not affected. The data implicate theExpand
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Auditory and visual dysfunction following lead exposure.
The effects of lead exposure on cognitive function have been intensively studied during the past decade, but relatively little effort has been made to understand the impact on sensory function.Expand
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