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Survival and desferrioxamine in thalassaemia major.
A small randomised trial and observation of all patients homozygous for beta-thalassaemia in Britain born in or before 1963 indicated that those patients who had received average weekly doses of more… Expand
A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo.
- D. Knight, A. H. Smith, +9 authors W. R. Tracey
- The Journal of pharmacology and experimental…
- 1 April 2001
Zoniporide represents a novel class of potent NHE-1 inhibitors with potential utility for providing clinical cardioprotection and did not cause any in vivo hemodynamic changes. Expand
NO modulates myocardial O2 consumption in the nonhuman primate: an additional mechanism of action of amlodipine.
The results indicate that NO can reduce oxygen consumption in the primate myocardium in vitro, and they support a role for the calcium-channel blocker amlodipine as a modulator of myocardial oxygen consumption via a kinin-NO mediated mechanism. Expand
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.
- W. R. Tracey, W. Magee, +4 authors D. Knight
- American journal of physiology. Heart and…
- 14 August 2003
CP-532,903 and CP-608,039 represent a novel class of human A3 receptors-selective agonists that may prove suitable for investigation of the clinical cardioprotective efficacy of A3 receptor activation. Expand
Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey.
- K. Kavanagh, D. Flynn, C. Nelson, L. Zhang, J. D. Wagner
- Biology, Medicine
- Journal of pharmacological and toxicological…
- 1 May 2011
The lower dose of STZ (45 mg/kg) significantly improved the toxicity profile without altering efficacy in inducing DM, and sufficient time following induction is recommended to allow transient renal, hepatic and hematologic parameters to resolve. Expand
Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical Progress
Chelation therapy was associated with a significant reduction in liver iron concentration, and by the end of the trial the values for the two groups showed no overlap. Expand
A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion.
There is strong evidence that treatment with a unique carbohydrate analog of SLeX, CY-1503, significantly reduces the degree of myocardial injury associated with coronary artery ischemia and reperfusion and the profound cardioprotection appears to be related to a reduction in PMN accumulation within the ischemic-reperfused myocardium. Expand
Hormonal changes in thalassaemia major.
The endocrine status of 31 thalassaemic patients aged 2-5 to 23 years was investigated and there was an overall tendency for FSH and LH excretion to be low with regard to age, but with respect to puberty rating FSH exretions were normal or low and LH normal or raised. Expand
Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion.
In contrast, P-selectin immunoneutralization reduced PMN accumulation and myocardial tissue injury in a canine model of coronary occlusion and reperfusion, and treatment with MAb PB1.3 failed to preserve postischemicMyocardial blood flow or myocardIAL contractility. Expand
Combined inhibition of P-selectin and ICAM-1 reduces myocardial injury following ischemia and reperfusion.
The coadministration of anti-P-selectin and anti-ICAM-1 monoclonal antibodies does not enhance the degree of myocardial protection in this model of reperfusion injury, and was not superior to treatment with either antibody alone. Expand