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Cell mechanics and the cytoskeleton
The ability of a eukaryotic cell to resist deformation, to transport intracellular cargo and to change shape during movement depends on the cytoskeleton, an interconnected network of filamentousExpand
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Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis.
Uropathogenic Escherichia coli (UPEC) are capable of forming complex intracellular bacterial communities (IBC) within the superficial umbrella cells of the bladders of C3H and BALB/c mice. By usingExpand
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Force microscopy of nonadherent cells: a comparison of leukemia cell deformability.
Atomic force microscopy (AFM) has become an important tool for quantifying mechanical properties of biological materials ranging from single molecules to cells and tissues. Current AFM techniques forExpand
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Use the force: membrane tension as an organizer of cell shape and motility.
Many cell phenomena that involve shape changes are affected by the intrinsic deformability of the plasma membrane (PM). Far from being a passive participant, the PM is now known to physically, asExpand
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Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
The treelike structures of many organs, including the mammary gland, are generated by branching morphogenesis, a reiterative process of branch initiation and invasion from a preexisting epithelium.Expand
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Actin polymerization serves as a membrane domain switch in model lipid bilayers.
The ability of cells to mount localized responses to external or internal stimuli is critically dependent on organization of lipids and proteins in the plasma membrane. Involvement of the actinExpand
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Reversible stress softening of actin networks
The mechanical properties of cells play an essential role in numerous physiological processes. Organized networks of semiflexible actin filaments determine cell stiffness and transmit force duringExpand
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Membrane bending by protein–protein crowding
Curved membranes are an essential feature of dynamic cellular structures, including endocytic pits, filopodia protrusions and most organelles. It has been proposed that specialized proteins induceExpand
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Cytoplasmic Volume Modulates Spindle Size During Embryogenesis
Scaling Spindle Size The difficulty of modulating cell size in vivo has made it hard to test hypotheses for organelle size scaling during development. To this end, Hazel et al. (p. 853) and Good etExpand
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Loading history determines the velocity of actin-network growth
Directional polymerization of actin filaments in branched networks is one of the most powerful force-generating systems in eukaryotic cells. Growth of densely cross-linked actin networks drives cellExpand
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