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Genetic Variants Regulating Immune Cell Levels in Health and Disease
The complex network of specialized cells and molecules in the immune system has evolved to defend against pathogens, but inadvertent immune system attacks on "self" result in autoimmune disease. BothExpand
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Mutation of the angiopoietin‐1 gene (ANGPT1) associates with a new type of hereditary angioedema
Background: Hereditary angioedema (HAE) is a rare genetic disease usually caused by mutation in the C1 inhibitor or the coagulation Factor XII gene. However, in a series of patients with HAE, noExpand
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Overexpression of the Cytokine BAFF and Autoimmunity Risk
BACKGROUND Genomewide association studies of autoimmune diseases have mapped hundreds of susceptibility regions in the genome. However, only for a few association signals has the causal gene beenExpand
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Exercise and asthma: an overview
The terms ‘exercise-induced asthma’ (EIA) and ‘exercise-induced bronchoconstriction’ (EIB) are often used interchangeably to describe symptoms of asthma such as cough, wheeze, or dyspnoea provoked byExpand
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EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders
Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example, a cytokine or receptor. InExpand
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SAPHO Syndrome: Current Developments and Approaches to Clinical Treatment
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. ItsExpand
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Characterization of patients with angioedema without wheals: the importance of F12 gene screening.
Sporadic and familiar forms of non-histaminergic angioedema and normal C1 inhibitor encompass a group of disorders possibly caused by bradikinin. We aimed to study the subgroups of hereditaryExpand
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Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force
To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccineExpand
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Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis
Zinc is an essential trace element for living organisms and their biological processes. Zinc plays a key role in more than 300 enzymes and it is involved in cell communication, proliferation,Expand
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TH17 cells are increased in the peripheral blood of patients with SAPHO syndrome
Abstract To assess whether the immune derangement previously observed in SAPHO syndrome could be linked to variations in blood TH1, TH2 or TH17 lymphocytes frequency. Seven SAPHO patients with aExpand
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