• Publications
  • Influence
IL-10 inhibits cytokine production by activated macrophages.
TLDR
The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses. Expand
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
TLDR
Biochemical characterization, mAbs, and recombinant or purified cytokines showed that CSIF is distinct from IL-1,IL-2, IL-3, IFN-gamma, GM-CSF, TGF-beta, TNF, LT, and P40, and the potential role of CSIF in crossregulation of Th1 and Th2 responses is discussed. Expand
The mechanism of action of cyclosporin A and FK506.
TLDR
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways by creating composite surfaces that block the activity of specific targets. Expand
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
TLDR
IL-10 may inhibit macrophage accessory cell function which is independent of TCR-class II MHC interactions, as well as inhibits IL-2-induced IFN-gamma production by Th1 cells in an Ag-free system requiring only the presence of accessory cells. Expand
Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.
TLDR
The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host. Expand
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.
TLDR
Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but B CRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL -10 activities. Expand
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
TLDR
FKBP12-rapamycin does not appear to inhibit the kinase activity of TOR proteins in a general way; instead, it may interfere selectively with TOR protein binding to or phosphorylation of G1 effectors. Expand
Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1.
TLDR
Recombinant B CRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system. Expand
Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells
TLDR
Two major patterns of cytokine synthesis were initially recognized, and these two patterns appear to correlate with the induction of delayed-type hypersensitivity and help for antibody synthesis, thus providing a possible explanation for the separate and often reciprocal regulation of these two responses. Expand
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
TLDR
The findings reveal that immunophilins interact with calcineurin in the absence of exogenous ligands and suggest that immunosuppressants may take advantage of the inherent ability of immunophILins to interact with Calcineur in vivo. Expand
...
1
2
3
...