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Genetic Analysis of Ephrin-A2 and Ephrin-A5 Shows Their Requirement in Multiple Aspects of Retinocollicular Mapping
Ephrin-A2 and -A5 are thought to be anteroposterior mapping labels for the retinotectal/retinocollicular projection. Here, gene disruptions of both these ephrins are characterized. Focal retinalExpand
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Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
The interactions between Eph receptor tyrosine kinases and their ephrin ligands regulate cell migration and axon pathfinding. The EphA receptors are generally thought to become activated by ephrin-AExpand
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Topographic Guidance Labels in a Sensory Projection to the Forebrain
Visual connections to the mammalian forebrain are known to be patterned by neural activity, but it remains unknown whether the map topography of such higher sensory projections depends on axonExpand
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Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex
SECRETORY-protein translocation into the endoplasmic reticulum (ER) is thought to be catalysed by integral membrane proteins. Genetic selections uncovered three Saccharomyces cerevisiae genes (SEC61,Expand
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Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping
In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here weExpand
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Spatial-Temporal Patterns of Retinal Waves Underlying Activity-Dependent Refinement of Retinofugal Projections
During development, retinal axons project coarsely within their visual targets before refining to form organized synaptic connections. Spontaneous retinal activity, in the form ofExpand
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Ephrin-As Guide the Formation of Functional Maps in the Visual Cortex
Ephrin-As and their receptors, EphAs, are expressed in the developing cortex where they may act to organize thalamic inputs. Here, we map the visual cortex (V1) in mice deficient for ephrin-A2, -A3,Expand
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Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.
SEC63 encodes a protein required for secretory protein translocation into the endoplasmic reticulum (ER) of Saccharomyces cerevisiae (J. A. Rothblatt, R. J. Deshaies, S. L. Sanders, G. Daum, and R.Expand
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Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos.
Publisher Summary Polypeptide ligands and their cell surface receptors bind to one another with high affinity and specificity. These biological properties can be exploited to make affinity probes toExpand
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Ephrin-As and Patterned Retinal Activity Act Together in the Development of Topographic Maps in the Primary Visual System
The development of topographic maps in the primary visual system is thought to rely on a combination of EphA/ephrin-A interactions and patterned neural activity. Here, we characterize theExpand
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