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Adjunctive Intranasal Oxytocin Reduces Symptoms in Schizophrenia Patients
TLDR
The hypothesis that oxytocin has antipsychotic properties and is well tolerated is supported and higher doses and longer duration of treatment may produce larger benefits and should be evaluated in future studies. Expand
Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
TLDR
Findings of sensorimotor gating deficits among bipolar disorder patients are consistent with other findings using different measures of information processing and suggest that the neurobiological substrates underlying sensorim motor gating may be dysregulated during acute manic and psychotic states. Expand
Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating
TLDR
The results suggest that oxytocin may play an important role in the modulation of dopaminergic and glutamatergic regulation of PPI, and that it may act as a novel endogenous antipsychotic. Expand
Extended release quetiapine fumarate monotherapy in major depressive disorder: a placebo- and duloxetine-controlled study.
TLDR
Quetiapine XR monotherapy is effective, with safety and tolerability consistent with the known profile of quetiapsin XR, in the treatment of patients with MDD, with onset of symptom improvement demonstrated at week 1. Expand
Attitudes toward psychiatry as a prospective career among students entering medical school.
TLDR
An erosion has occurred over the past two decades in the attitudes that new medical students hold toward psychiatry, and some of the negative attitudes are based on objectifiably false beliefs that should be actively targeted for remediation within the medical school curriculum. Expand
Inhibitory deficits in ocular motor behavior in adults with attention-deficit/hyperactivity disorder
TLDR
Findings support the notion that deficits in inhibitory mechanisms might underlie the inattention characteristic of ADHD and implicate abnormalities in prefrontal cortex-basal ganglia circuitry in ADHD. Expand
A systematic review of modafinil: Potential clinical uses and mechanisms of action.
TLDR
The strongest evidence among off-label uses exists for the use of modafinil in attention-deficit disorder, postanesthetic sedation, and cocaine dependence and withdrawal and as an adjunct to antidepressants for depression. Expand
The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle
TLDR
The data suggest that systemically administered NT1 agonists modulate the neural circuitry that regulates fear and anxiety to produce dose-dependent anxiolytic-like effects on FPS. Expand
The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance
TLDR
The results indicated that repeated daily administration of PD149163 was able to antagonize amphetamine’s locomotor-activating effect comparable to that of the first dose, despite that repeated administration ofPD149163 produced an increase in baseline locomotor activity not seen after the firstdose. Expand
The effects of intra-accumbens neurotensin on sensorimotor gating
Abstract Neurotensin is a neuropeptide which coexists with mesolimbic dopamine. Previous studies have shown that centrally administered neurotensin can modulate the activity of mesolimbic dopamineExpand
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