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Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone
We have identified a novel natural metabolite, ilimaquinone (IQ), from sea sponges that causes Golgi membranes to break down completely in vivo into small vesicular structures (called vesiculatedExpand
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A brominated secondary metabolite synthesized by the cyanobacterial symbiont of a marine sponge and accumulation of the crystalline metabolite in the sponge tissue
The dictyoceratid marine sponge Dysidea herbacea (Keller, 1889) is common in shallow waters of the tropical Pacific Ocean. Polybrominated biphenyl ethers such asExpand
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Two classes of metabolites fromTheonella swinhoei are localized in distinct populations of bacterial symbionts
The marine spongeTheonella swinhoei (lithistid Family Theonellidae, Order Astrophorida) has yielded many important, bioactive natural products, most of which share structural features with bacterialExpand
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Antibiotic Metabolites from a Marine Pseudomonad
An antibiotic-producing pseudomonad was isolated from a seawater sample from a La Jolla, Calif., tidepool. The pseudomonad produces two novel antibacterial compounds, 2-n-pentyl-4-quinolinol andExpand
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Size-dependent absolute quantum yields for size-separated colloidally-stable silicon nanocrystals.
Size-selective precipitation was used to successfully separate colloidally stable allylbenzene-capped silicon nanocrystals into several visible emitting monodisperse fractions traversing the quantumExpand
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Microbial symbionts of marine invertebrates: opportunities for microbial biotechnology.
Marine invertebrates are sources of a diverse array of bioactive metabolites with great potential for development as drugs and research tools. In many cases, microorganisms are known or suspected toExpand
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Identification of okadaic acid from a Caribbean dinoflagellate, Prorocentrum concavum.
Lipid-soluble toxins were isolated from a Caribbean strain of the epiphytic dinoflagellate Prorocentrum concavum Fukuyo. The major lipid-soluble toxin (LD50 = 210 +/- 15 micrograms/kg i.p. in mice)Expand
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The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol.
The predominant low-molecular-mass thiol produced by streptomycetes is a cysteine derivative previously designated as U17 [Newton, G. L., Fahey, R. C., Cohen, G. & Aharonowitz, Y. (1993) J.Expand
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Screening and bioassays for biologically-active substances from forty marine sponge species from San Diego, California, USA
Biologically-active substances were investigated from 35 demosponge species and 5 calcareous sponge species collected from intertidal or shallow subtidal habitats near San Diego, California, USA,Expand
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Cyanobacterial symbiont biosynthesis of chlorinated metabolites fromDysidea herbacea (Porifera)
The tropical marine spongeDysidea herbacea contains large numbers of a symbiotic filamentous cyanobacterium identified on the basis of a detailed ultrastructural study asOscillatoria spongeliae. WeExpand
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