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Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses.
- G. Bohach, D. Fast, R. D. Nelson, P. Schlievert
- Biology, Medicine
- Critical reviews in microbiology
Toxic-shock syndrome (TSS) is an acute onset, multiorgan illness which resembles severe scarlet fever. The illness is caused by Staphylococcus aureus strains that express TSS toxin-1 (TSST-1),… Expand
Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production.
Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1,… Expand
Cyclosporin A inhibits nitric oxide production by L929 cells in response to tumor necrosis factor and interferon-gamma.
We recently reported that tumor necrosis factor (TNF) induced the production of nitric oxide (NO) by TNF-sensitive, but not-resistant, tumor cells. Paradoxically, NO thus produced does not appear to… Expand
Nitric oxide production by tumor targets in response to TNF: paradoxical correlation with susceptibility to TNF‐mediated cytotoxicity without direct involvement in the cytotoxic mechanism
Tumor necrosis factor (TNF) is selectively cytotoxic for some tumor cells in vivo and in vitro. We determined whether TNF‐mediated cytotoxicity for TNF‐sensitive tumor targets was related to… Expand
Nonpurulent response to toxic shock syndrome toxin 1-producing Staphylococcus aureus. Relationship to toxin-stimulated production of tumor necrosis factor.
Infection of surgical wounds with toxic shock syndrome toxin 1 (TSST-1)-producing Staphylococcus aureus does not usually elicit a purulent response from the host. Because S. aureus is normally a… Expand
IFN-gamma differentially modulates the susceptibility of L1210 and P815 tumor targets for macrophage-mediated cytotoxicity. Role of macrophage-target interaction coupled to nitric oxide generation,…
IFN-gamma primes murine macrophages to render them responsive for triggering by subactivating concentrations of bacterial LPS to mediate nonspecific tumor cytotoxicity. However, IFN-gamma also has… Expand
Mechanistic differences between migration inhibitory factor (MIF) and IFN-gamma for macrophage activation. MIF and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma…
Previously we found that murine macrophage migration inhibition (MMI) was mediated by IFN-gamma-priming and lipid A triggering. With the recent availability of human recombinant migration inhibitory… Expand
Staphylococcal exotoxins stimulate nitric oxide-dependent murine macrophage tumoricidal activity.
- D. Fast, B. Shannon, M. Herriott, M. Kennedy, J. Rummage, R. Leu
- Biology, Medicine
- Infection and immunity
- 1 September 1991
The staphylococcal exotoxins toxic shock syndrome toxin 1 (TSST-1) and enterotoxin B were tested for their ability to stimulate murine peritoneal macrophages (PM) for tumoricidal activity. Both… Expand
Pathogenesis of candidiasis. Immunosuppression by cell wall mannan catabolites.
Candida albicans cell wall mannan polysaccharide has an ability to negatively influence cell-mediated immune function. We have attempted to identify the mechanism of this phenomenon by testing the… Expand
Transfection of L929 cells with complement subcomponent C1q B-chain antisense cDNA inhibits tumor necrosis factor-alpha binding to mediate cytotoxicity and nitric oxide generation.
- H. Jiang, C. Stewart, S. Y. Tan, D. Fast, J. Rummage, R. Leu
- Biology, Medicine
- Cellular immunology
- 1 February 1996
The role of complement subcomponent C1q in the modulation of TNF-alpha binding to L929 cells to mediate cytotoxicity and nitric oxide (NO) generation was investigated. Transfection of L929 with… Expand