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Lucibufagins: Defensive steroids from the fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae).
Feeding tests with thrushes led to the isolation of three novel steroid pyrones from fireflies responsible, in part at least, for the unpalatability of these insects to the birds. Expand
Naphthoquinones in defensive secretion of an opilionid
The defensive secretion of the opilionidPhalangium opilio contains 1,4-naphthoquinone and 6-methyl-1,2,3, and 1,6-methine, both of rate occurrence in arthropods, having previously been reported only from certain tenebrionid beetles. Expand
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
The Hp fraction and selected constituents from this fraction showed evidence of blocking pro-inflammatory mediators but not enhancing inflammation-suppressing mediators. Expand
Synthesis and biological activity of isoprenoid bisphosphonates.
A set of dialkyl bisphosphonates bearing isoprenoid chains of varying lengths has been synthesized and some of these compounds were found to have biological activity on post-translational processing of the oncogenic small GTPases, Ras and Rap1a, in human-derived K562 leukemia cells. Expand
Geranylgeranyl Diphosphate Synthase: An Emerging Therapeutic Target
The advances in (and the challenges of) validation of GGDPS as a novel therapeutic target are described and the advantages of targetingGGDPS relative to other enzymes involved in geranylgeranylation are assessed. Expand
Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents
The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea, Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing anti-viral,Expand
Isoprenoid metabolism as a therapeutic target in gram-negative pathogens.
Current knowledge of the biochemical pathways involved in farnesyl diphosphate metabolism in Enterobacteria, efforts to develop inhibitors of the involved enzymes, and insights from inhibitors of human isoprenoid metabolism that may be relevant for future studies of antibiotics that target these key enzymes, are described. Expand
Flavanones from Lonchocarpus minimiflorus
Abstract Five novel flavanones have been isolated from the leaves of the Costa Rican tree Lonchocarpus minimiflorus , and characterized on the basis of their spectral features. Three of theseExpand
Piplaroxide, an ant-repellent piperidine epoxide from Piper tuberculatum
Investigation of leaves from the shrub Piper tuberculatum for compounds that might serve as repellents to leafcutting ants has led to identification of three cinnamic acid derivatives. One has beenExpand