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Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice.
Two macrocyclic 14C-pyrrolizidine alkaloids (PA's), senecionine an seneciphylline, were studied regarding the distribution, excretion, transfer into milk, and covalent binding to hepatic
A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.
TLDR
The in vitro mouse hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid senecionine was studied by high-performance liquid chromatography using a muBondapak-C18 reverse-phase system and methods developed for the isolation of each individual metabolite.
Development of an Acute Model for the Study of Chloromethanediphosphonate Nephrotoxicity
TLDR
This model significantly reduces the time required to induce renal toxicity observed in routine toxicity studies from months of treatment to less than 1 week and will, thus, serve as a baseline for subsequent pathogenetic studies.