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Cassane diterpenes from the seed kernels of Caesalpinia sappan.
Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CDExpand
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Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata.
In a course of our search for anticancer agent based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Securidaca longepedunculata (Polygalaceae), collected atExpand
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Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities.
Muchimangins are benzophenone-xanthone hybrid polyketides produced by Securidaca longepedunculata. However, their biological activities have not been fully investigated, since they are minorExpand
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Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.
A series of new (-)-arctigenin derivatives with variably modified O-alkyl groups were synthesized and their preferential cytotoxicity was evaluated against human pancreatic cancer cell line PANC-1Expand
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Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibitExpand
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Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac.
Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circularExpand
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Muchimangins A–D: novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata
Abstract Two new highly oxygenated xanthones, named muchimangins E ( 1 ) and F ( 2 ), have been isolated from the root of Securidaca longepedunculata (Polygalaceae). Their structures were elucidatedExpand
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Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: A novel animal model of ASD
&NA; Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms of social impairments and restrictive repetitive behaviors. Recent evidence has implicated a dysfunction in theExpand
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Anti-austerity agents from Rhizoma et Radix Notopterygii (Qianghuo).
During a search for potent anticancer agents from natural products based on an anti-austerity strategy, we found that a CHCl3 extract of Rhizoma et Radix Notopterygii (Qianghuo), a Chinese crudeExpand
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Damnacanthal from the Congolese Medicinal Plant Garcinia huillensis has a Potent Preferential Cytotoxicity against Human Pancreatic Cancer PANC‐1 Cells
Screening of eight Congolese medicinal plants showed that the CHCl3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 µg/mL and 13.8 µg/mL, respectively) and CHCl3 extracts of Garcinia huillensisExpand
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