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The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
Z antitrypsin polymerized in vitro has identical properties and ultrastructure to the inclusions isolated from hepatocytes of a Z homozygote, and the concentration and temperature dependence of this loop-sheet polymerization has implications for the management of the liver disease of the newborn Z Homozygote. Expand
Apoptosis: a mechanism of cell killing by influenza A and B viruses
These studies indicate that influenza A and B viruses induce apoptosis in cell cultures; thus, apoptosis may represent a general mechanism of cell death in hosts infected with influenza viruses. Expand
Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry.
- C. Dive, C. Gregory, D. J. Phipps, D. Evans, A. Milner, A. Wyllie
- Biology, Medicine
- Biochimica et biophysica acta
- 3 February 1992
A novel and rapid multiparameter flow cytometric assay which discriminates and quantifies viable, apoptotic and necrotic cells via measurement of forward and side light scatter (proportional to cell diameter and internal granularity, respectively) and the DNA-binding fluorophores Hoechst 33342 and propidium is described. Expand
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin.
Z, like M antitrypsin, undergoes the S to R transition, but it is shown that the accompanying change in thermal stability results from loop-sheet polymerization (S), which can be prevented by the insertion of the cleaved strand of the reactive center loop into the A-sheet (R). Expand
Nitrogen Rate and Mowing Height Effects on TifEagle Bermudagrass Establishment
Evaluating the impact of N rate and mowing height on the percentage ground cover, shoot density, color, total nonstructural carbohydrate (TNC) content, and soil nitrate and ammonium content of TifEagle hybrid bermudagrass putting greens found that almost every agronomic measure responded to increased applications of N. Expand
Induction of c-fos mRNA in rat medial prefrontal cortex by antipsychotic drugs: role of dopamine D2 and D3 receptors.
It is hypothesize that blockade of D3 receptors may enhance c-fos gene expression in the medial prefrontal cortex but that of D2 receptors may prevent the same, as well as U-99194A, an antagonist with 20-fold selectivity for D3 over D2 receptor that produced greater induction of c- fos mRNA at lower doses. Expand
Identification of a putative antigen receptor on fish nonspecific cytotoxic cells with monoclonal antibodies.
- D. Evans, L. Jaso-Friedmann, E. Smith, A. S. St. John, H. Koren, D. Harris
- Biology, Medicine
- Journal of immunology
- 1 July 1988
It is demonstrated that the Ag-binding receptor structure on fish NCC may be comprised of a dimeric complex that is composed of 41 kDa and 38 kDa proteins. Expand
Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation.
Results imply that in contrast to engagement of thymocyte apoptosis by methylprednisolone and etoposide, where apoptosis was proliferation independent, cisplatin-induced apoptosis depends on the presence of cells in S and G2-M phases of the cell cycle. Expand
Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor.
- D. Lomas, D. Evans, C. Upton, G. McFadden, R. Carrell
- Medicine, Biology
- The Journal of biological chemistry
- 5 January 1993
Structural analysis and kinetic assays demonstrate that the absence of the D-helix does not prevent inhibitory activity and furthermore allow the identification of cysteine residues involved in internal and intermolecular disulfide bonding. Expand
Nonspecific cytotoxic cell receptor protein-1: a novel (predicted) type III membrane receptor on the teleost equivalent of natural killer cells recognizes conventional antigen.
The phylogenetic model for "conventional" antigen recognition by NK cells may be a protein recently identified from catfish nonspecific cytotoxic cells (NCC), and the antigen binding domain was identified by competition experiments using synthetic peptides. Expand