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- Publications
- Influence
DNA mismatch repair.
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA… Expand
Multiple RNA polymerase conformations and GreA: control of the fidelity of transcription.
- D. Erie, O. Hajiseyedjavadi, M. Young, P. V. von Hippel
- Biology, Medicine
- Science
- 5 November 1993
Pre-steady state kinetics of misincorporation were used to investigate the addition of single nucleotides to nascent RNA by Escherichia coli RNA polymerase during transcription elongation. The… Expand
Eukaryotic Mismatch Repair in Relation to DNA Replication.
Three processes act in series to accurately replicate the eukaryotic nuclear genome. The major replicative DNA polymerases strongly prevent mismatch formation, occasional mismatches that do form are… Expand
Structural Model for Deoxycytidine Deamination Mechanisms of the HIV-1 Inactivation Enzyme APOBEC3G*♦
- L. Chelico, Courtney Prochnow, D. Erie, X. Chen, M. Goodman
- Biology, Medicine
- The Journal of Biological Chemistry
- 8 March 2010
APOBEC3G (Apo3G) is a single-stranded DNA-dependent deoxycytidine deaminase, which, in the absence of the human immunodeficiency virus (HIV) viral infectivity factor, is encapsulated into HIV… Expand
Interconvertible Lac Repressor–DNA Loops Revealed by Single-Molecule Experiments
- Oi Kwan Wong, M. Guthold, D. Erie, J. Gelles
- Biology, Chemistry
- PLoS biology
- 1 September 2008
At many promoters, transcription is regulated by simultaneous binding of a protein to multiple sites on DNA, but the structures and dynamics of such transcription factor-mediated DNA loops are poorly… Expand
DNA bending and unbending by MutS govern mismatch recognition and specificity
- H. Wang, Y. Yang, +8 authors D. Erie
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 21 November 2003
DNA mismatch repair is central to the maintenance of genomic stability. It is initiated by the recognition of base–base mismatches and insertion/deletion loops by the family of MutS proteins.… Expand
Allosteric Binding of Nucleoside Triphosphates to RNA Polymerase Regulates Transcription Elongation
- J. Foster, S. F. Holmes, D. Erie
- Medicine, Biology
- Cell
- 27 July 2001
The regulation of transcription elongation and termination appears to be governed by the ability of RNA polymerase elongation complexes to adopt multiple conformational states; however, the factors… Expand
The single-nucleotide addition cycle in transcription: a biophysical and biochemical perspective.
- D. Erie, T. Yager, P. V. von Hippel
- Biology, Medicine
- Annual review of biophysics and biomolecular…
- 1992
This review has summarized the known features of the single-nucleotide addition reaction cycle in transcription. The reader will have noted that the information available is very incomplete, and… Expand
The many conformational states of RNA polymerase elongation complexes and their roles in the regulation of transcription.
- D. Erie
- Biology, Medicine
- Biochimica et biophysica acta
- 13 September 2002
Transcription is highly regulated both by protein factors and by specific RNA or DNA sequence elements. Central to this regulation is the ability of RNA polymerase (RNAP) to adopt multiple… Expand
Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.
- Elizabeth J. Sacho, F. Kadyrov, P. Modrich, T. Kunkel, D. Erie
- Biology, Medicine
- Molecular cell
- 18 January 2008
MutL alpha, the heterodimeric eukaryotic MutL homolog, is required for DNA mismatch repair (MMR) in vivo. It has been suggested that conformational changes, modulated by adenine nucleotides, mediate… Expand