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Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition
- Siming Zhao, S. Bellone, +44 authors A. Santin
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 10 October 2016
The genomes of uterine and ovarian CSs demonstrated that these different cell types derive from a common precursor cell that has many mutations typical of epithelial cancers, and expression of specific histone gene mutations in uterine carcinoma cells changed gene expression toward a mesenchymal state. Expand
Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice
In this largest comprehensive study, 35% of endometrial serous carcinoma harbors HER2 protein overexpression and/or gene amplification, over half of which demonstrate significant heterogeneity of protein expression. Expand
Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo.
- S. Lopez, Carlton L. Schwab, +7 authors A. Santin
- Biology, Medicine
- Gynecologic oncology
- 1 November 2014
Taselisib represents a novel therapeutic option in patients harboring PIK3CA mutations and/or HER2/neu gene amplification and dose-dependent decline in the phosphorylation of S6 in the G0/G1 phase of the cell cycle. Expand
Past, present and future targets for immunotherapy in ovarian cancer.
- Carlton L. Schwab, D. English, D. Roque, M. Pasternak, A. Santin
- 19 December 2014
The different immunotherapies available for ovarian cancer as well as current ongoing studies and potential future directions are reviewed. Expand
HER2 Expression Beyond Breast Cancer: Therapeutic Implications for Gynecologic Malignancies
Tyrosine kinase inhibitors and immunotherapy with monoclonal antibodies targeting HER2 hold promise for patients harboring these aggressive neoplasms. Expand
Claudins Overexpression in Ovarian Cancer: Potential Targets for Clostridium Perfringens Enterotoxin (CPE) Based Diagnosis and Therapy
These surface proteins may represent attractive targets for the detection and treatment of chemotherapy-resistant ovarian cancer and other aggressive solid tumors overexpressing claudin-3 and -4 using CPE-based theranostic agents. Expand
PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas
Oncogenic PIK3CA mutations are common in HER2/neu-amplified USC and may constitute a major mechanism of resistance to trastuzumab treatment. Expand
Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR…
- D. English, S. Bellone, +7 authors A. Santin
- Biology, Medicine
- American journal of obstetrics and gynecology
- 1 November 2013
Oncogenic PIK3CA mutations and c-erbB2 gene amplification may represent biomarkers to identify patients harboring USC who may benefit most from the use of GDC-0980. Expand
Platinum desensitization in patients with carboplatin hypersensitivity: A single-institution retrospective study.
This is the largest study of its kind showing a safe, effective and rapid (3.5h) CD protocol and the majority of patients with a history of either carboplatin hypersensitivity reaction or a positive skin test completed the CD protocol without HSRs. Expand
Neratinib shows efficacy in the treatment of HER2/neu amplified uterine serous carcinoma in vitro and in vivo.
Neratinib may be a potential treatment option for patients harboring HER2/neu amplified USC and clinical trials for this subset of endometrial cancer patients are warranted. Expand