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A long‐term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag‐2–deficient mice
An immortalized, cloned liver cell line is established by transferring the Simian Virus 40 Large T‐Antigen into primary human hepatocytes to establish a new murine model of HBV viremia that should be useful for in vivo HBV studies.
Adoptive transfer of regulatory NKT lymphocytes ameliorates non‐alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping
A role for regulatory NKT lymphocytes in the pathogenesis of non‐alcoholic steatohepatitis in the leptin‐deficient murine model is supported, with effects associated with decreased peripheral and intrahepatic CD4/CD8 ratios and decreased interleukin 10 levels.
Glucocerebroside Ameliorates the Metabolic Syndrome in OB/OB Mice
- M. Margalit, Z. Shalev, Y. Ilan
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 October 2006
Marked amelioration of the metabolic alterations characteristic of leptin-deficient mice was observed in GC-treated animals compared with controls, and immune modulation by GC may have a role in the treatment of nonalcoholic steatohepatitis and other immune-mediated disorders.
Interferon Action: Inhibition of Vesicular Stomatitis Virus RNA Synthesis Induced by Virion-Bound Polymerase
The particle-bound RNA polymerase activity of vesicular stomatitis virus (VSV) can be demonstrated in vivo and autoradiographs show the physical distribution, in cells, of RNA produced by virion polymerase in the absence of translation—a demonstration of the transcription product of the viral genome.
Treatment of experimental colitis by oral tolerance induction: a central role for suppressor lymphocytes
- Y. Ilan, S. Weksler-Zangen, E. Goldin
- Medicine, BiologyAmerican Journal of Gastroenterology
- 1 April 2000
Induction of oral tolerance to colitis-extracted proteins downregulates the anticolon immune response, thereby ameliorating experimental colitis, and whether oral tolerization mediated by suppressor cells can induce immune tolerance.
HOST-DEPENDENT MUTANTS OF THE BACTERIOPHAGE F2. 3. INFECTIVE RNA.
The regulation of protein synthesis in animal cells by serum factors.
A translational control mechanism is operative in Vero cells deprived of serum and a temporal correlation exists among the in vivo rate of protein synthesis, the peptide synthetic activity of cell-free extracts, and the activity of elongation factor I.
A monoclonal antibody to vasopressin: preparation, characterization, and application in immunocytochemistry.
- A. Hou-Yu, P. Ehrlich, E. Zimmerman
- BiologyThe journal of histochemistry and cytochemistry…
- 1 December 1982
Tissue fixation with formaldehyde resulted in inadequate immunostaining as compared to glutaraldehyde, most likely due to interference with the aromatic amino acid determinants by the former fixative.
Peptide coding capacity of polysomal and non-polysomal messenger RNA during growth of animal cells.
Identification of a distinct phase during melanogenesis that is sensitive to extracellular pH and ionic strength
- J. Laskin, R. A. Mufson, I. Weinstein, D. Engelhardt
- BiologyJournal of cellular physiology
- 1 June 1980
The cell line B16/C3 will undergo melanogenesis at a specific time after plating, and this time can be modulated by varying the pH of the culture medium, which is sensitive to the extracellular ionic strength.