• Publications
  • Influence
A Grb2-associated docking protein in EGF- and insulin-receptor signalling
THE protein Grb2 plays a central role in signalling by receptor protein-tyrosine kinases1,2, where its SH2 domain binds to the receptor and its two SH3 domains link to effectors. One target effectorExpand
  • 662
  • 57
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.
Nerve growth factor (NGF) prevents apoptosis through stimulation of the TrkA receptor protein tyrosine kinase. The downstream activation of phosphatidylinositol 3-kinase (PI 3-kinase) is essentialExpand
  • 271
  • 20
Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor*
The most frequently found alteration of the epidermal growth factor receptor (EGFR) in human tumors is a deletion of exons 2–7. This receptor, termed EGFRvIII, can transform NIH 3T3 cells, and theExpand
  • 308
  • 17
Subsets of Epidermal Growth Factor Receptors during Activation and Endocytosis*
Mutation of the autophosphorylation sites of receptor protein-tyrosine kinases alters ligand dependent internalization and down-regulation, indicating a critical role for these sites in receptorExpand
  • 78
  • 7
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) byExpand
  • 137
  • 4
Targeting a glioblastoma cancer stem-cell population defined by EGF receptor variant III.
The relationship between mutated proteins and the cancer stem-cell population is unclear. Glioblastoma tumors frequently express EGFRvIII, an EGF receptor (EGFR) variant that arises via geneExpand
  • 92
  • 4
  • PDF
Elevated JNK activation contributes to the pathogenesis of human brain tumors
The ERK pathway is typically associated with activation of the EGF receptor and has been shown to play a major role in promoting several tumor phenotypes. An analogous signaling module, the JNKExpand
  • 97
  • 4
  • PDF
Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors.
The c-Jun NH(2)-terminal kinases (JNKs) have a role both in promoting apoptosis and tumorigenesis. The JNKs are encoded by three separate genes (JNK1, 2, and 3), which are spliced alternatively toExpand
  • 102
  • 3
  • PDF
Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors.
Cell surface adhesion molecules are crucial for the development and/or pathogenesis of various diseases including cancer. CD44 has received much interest as a major adhesion molecule that is involvedExpand
  • 145
  • 2
Expression of constitutively activated EGFRvlll in non‐small cell lung cancer
The epidermal growth factor receptor (EGFR) variant type III (variously called EGFRvlll, de2–7 EGFR or ΔGFR) has an in‐frame deletion of the extracellular domain and is found in numerous types ofExpand
  • 125
  • 1