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Poly(l-lysine)-g-poly(ethylene glycol) Layers on Metal Oxide Surfaces: Surface-Analytical Characterization and Resistance to Serum and Fibrinogen Adsorption
Poly(l-lysine)-g-poly(ethylene glycol) (PLL-g-PEG) is a member of a family of polycationic PEG-grafted copolymers that have been shown to chemisorb on anionic surfaces, including various metal oxide… Expand
Amyloid‐β efflux from the central nervous system into the plasma
The aim of this study was to measure the flux of amyloid‐β (Aβ) across the human cerebral capillary bed to determine whether transport into the blood is a significant mechanism of clearance for Aβ… Expand
Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering.
PEG-diacrylamide was synthesized and utilized to make materials for tissue engineering. Acrylamide groups readily react with thiol groups, and peptides containing a single thiol group were coupled to… Expand
Surface Treatments of Polymers for Biocompatibility
Biological recognition mediates cell and tissue interactions with biomaterials, be the materials employed in a biotechnical environment in vitro or a biomedical environment in vivo. These… Expand
Protein delivery from materials formed by self-selective conjugate addition reactions.
- D. Elbert, A. Pratt, M. Lutolf, S. Halstenberg, J. Hubbell
- Medicine, Chemistry
- Journal of controlled release : official journal…
- 11 September 2001
A new chemical cross-linking scheme was utilized for the formation of degradable poly(ethylene glycol) hydrogels suitable for the delivery of protein drugs. An aqueous solution containing a… Expand
Age and amyloid effects on human central nervous system amyloid‐beta kinetics
Age is the single greatest risk factor for Alzheimer's disease (AD), with the incidence doubling every 5 years after age 65. However, our understanding of the mechanistic relationship between… Expand
Poly(l-lysine)-g-Poly(ethylene glycol) Layers on Metal Oxide Surfaces: Attachment Mechanism and Effects of Polymer Architecture on Resistance to Protein Adsorption†
The generation of surfaces and interfaces that are able to withstand protein adsorption is a major challenge in the design of blood-contacting materials for both medical implants and bioaffinity… Expand
Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers.
BACKGROUND We present the synthesis, characterization and initial structure-function analysis of a new class of bioactive agent that allows the application of techniques from colloid science to… Expand
Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen.
- E. Scott, Michael D. Nichols, Rebecca Kuntz-Willits, D. Elbert
- Medicine, Materials Science
- Acta biomaterialia
Modular, bioactive, macroporous scaffolds were formed by crosslinking poly(ethylene glycol) (PEG) microspheres around living cells. Hydrogel microspheres were produced from reactive PEG derivatives… Expand
Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels.
Direct reprogramming strategies enable rapid conversion of somatic cells to cardiomyocytes or cardiomyocyte-like cells without going through the pluripotent state. A recently described protocol… Expand