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Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD).
Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with singleExpand
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Home base behavior of rats (Rattus norvegicus) exploring a novel environment
When rats are placed in a novel environment, they alternate between progression and stopping: in the course of a session they stop briefly in many places, but in one or two places they also stop forExpand
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Biphasic effect of D-2 agonist quinpirole on locomotion and movements.
The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of theExpand
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Die hard: A blend of freezing and fleeing as a dynamic defense—implications for the control of defensive behavior
  • D. Eilam
  • Biology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 31 December 2005
Freezing, fleeing or fighting back are general defensive responses in many taxa. These defenses are mutually exclusive, since a prey cannot simultaneously flee and fight, or freeze and flee. Each ofExpand
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Threat detection: Behavioral practices in animals and humans
In contrast to a perceptible threat that releases freezing, fleeing and fighting, abstract potential threat elicits anxiety and vigilance. The prevalent view is that the larger the animal groups theExpand
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Locomotor activity in common spiny mice (Acomys cahirinuse): The effect of light and environmental complexity
  • D. Eilam
  • Biology, Medicine
  • BMC Ecology
  • 10 November 2004
BackgroundRodents typically avoid illuminated and open areas, favoring dark or sheltered environments for activity. While previous studies focused on the effect of these environmental attributes onExpand
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Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD).
Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly X 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with singleExpand
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Open-field behavior withstands drastic changes in arena size
  • D. Eilam
  • Mathematics, Medicine
  • Behavioural Brain Research
  • 16 June 2003
Individual voles were tested on successive days under increasing, decreasing, or randomly changing arena size. Locomotor behavior was adjusted to arena size by (i) preserving the same level ofExpand
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Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control
BackgroundA previous report showed that the open field behavior of rats sensitized to the dopamine agonist quinpirole satisfies 5 performance criteria for compulsive checking behavior. In an effortExpand
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Rituals, stereotypy and compulsive behavior in animals and humans
From a survey of the behavior of animals in the wild, in captivity, under the influence of psychoactive drugs and in a model of obsessive-compulsive disorder (OCD), we identify that the behavioralExpand
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