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Design of bioreactors suitable for plant cell and tissue cultures
Plant cell suspension cultures and hairy roots are potential sources of secondary metabolites and recombinant proteins. In contrast to traditionally grown “whole wild plants” or “whole transgenicExpand
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Bag bioreactor based on wave-induced motion: characteristics and applications.
Today wave-mixed bag bioreactors are common devices in modern biotechnological processes where simple, safe and flexible production has top priority. Numerous studies that have been published on exExpand
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CFD for Characterizing Standard and Single-use Stirred Cell Culture Bioreactors
Driven by global competition and rising cost pressure in the pharmaceutical industry, over the last ten years single-use bioreactors have been increasingly used for animal cell cultivations inExpand
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Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology
Disposable bioreactors have increasingly been incorporated into preclinical, clinical, and production-scale biotechnological facilities over the last few years. Driven by market needs, and, inExpand
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Scale‐up of adipose tissue‐derived mesenchymal stem cell production in stirred single‐use bioreactors under low‐serum conditions
Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single‐use stirred bioreactor types, have been shown to be a promising alternative to planarExpand
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Single-Use Technology in Biopharmaceutical Manufacture
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Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges
TLDR
This mini-review summarizes both the current state of the hMSC production process and the challenges which have to be taken into account when efficiently producing hMSCs for the clinical scale. Expand
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Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors
The fluid flow and suspension characteristics inside small-scale, stirred, single-use bioreactors were investigated experimentally and by means of computational fluid dynamics. The required impellerExpand
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Disposable bioreactors for plant liquid cultures at Litre‐scale
Driven by the demands of the market and the manufacturing industry, disposable bioreactors have gained in importance in cell culture‐based processes during the last 10 years. Today they are widelyExpand
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