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The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds.
(1990). The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-Related Compounds. Drug Metabolism Reviews: Vol. 22, No. 5, pp. 503-529.
Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases
The condensation of substituted aromatic aldehydes with 7-amino-4-methyl-quinolin-2(1H)-one (1) has lead to the isolation of quinolin-2(1H)-one derived Schiff bases (2–14). The copper(II) complexesExpand
In vitro anti-tumour effect of 1,10-phenanthroline-5,6-dione (phendione), [Cu(phendione)3](ClO4)2.4H2O and [Ag(phendione)2]ClO4 using human epithelial cell lines.
Results suggest that phendione and its Cu(II) and Ag(I) complexes may be capable of acting as highly effective anti-cancer therapies, which with careful administration could provide very potent and effective alternatives to cisplatin. Expand
In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)]x2H2O, [Cu(phen)2(mal)]x2H2O and [Mn(phen)2(mal)]x2H2O (malH2=malonic acid) using human cancer cells.
Results suggest that 1,10-phenanthroline and the three metal-phen complexes may have a therapeutic role to play in the successful treatment and management of cancer. Expand
Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase.
It is concluded that p38 MAP kinase is intrinsically involved in mediating the effect of daphnetin in A-498 cells, suggesting that this drug may act by promotion of cellular maturation, and consequently may represent a novel low toxic approach for the treatment of poorly differentiated RCCs. Expand
Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells.
It was shown that the ligand was capable of inhibiting the action of topoisomerase II, but this was lost following complexation, which suggests that TV117-FM may have a therapeutic role to play in the treatment of hepatocellular carcinoma. Expand
Synthesis, characterization and antimicrobial activity of a series of substituted coumarin-3-carboxylatosilver(I) complexes
A series of new coumarin-derived carboxylate ligands and their silver(I) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against a range ofExpand
Mechanism of action of coumarin and silver(I)-coumarin complexes against the pathogenic yeast Candida albicans.
Silver(I)-coumarin complexes demonstrate good anti-fungal activity and manifest a mode of action distinct to that of the conventional azole and polyene drugs thus raising the possibility of their use when resistance to conventional drug has emerged or in combination with such drugs. Expand
Synthesis and antimicrobial activity of copper(II) and silver(I) complexes of hydroxynitrocoumarins: X-ray crystal structures of [Cu(hnc)2(H2O)2] · 2H2O and [Ag(hnc)] (hncH =
Abstract [Cu(hnc)2(H2O)2] · 2H2O (1) [hncH = 4-hydroxy-3-nitro-2H-chromen-2-one] and [Ag(hnc)] (2) were prepared by deprotonating the hydroxy group of hncH with NaOH and then adding copper(II)Expand
Apoptotic cell death: a possible key event in mediating the in vitro anti-proliferative effect of a novel copper(II) complex, [Cu(4-Mecdoa)(phen)(2)] (phen=phenanthroline,
[Cu(4-Mecdoa)(phen)(2)] has been shown to be a more potent anti-proliferative agent than either the ligand or cisplatin, and is capable of altering key biochemical events leading to the execution of apoptotic and/or necrotic cell death, suggesting that it is worthy of further investigation. Expand