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Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.
TLDR
The effect of grapefruit juice on oral availability of CYP3A4 substrates can be largely accounted for by the presence of 6',7'-dihydroxybergamottin although other furanocoumarins probably also contribute. Expand
Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
TLDR
To examine the effect of grapefruit juice on the disposition of cyclosporine after administration of oral and intravenous doses to healthy male subjects, grapefruit Juice is used as a raw material for the drug conjugation test. Expand
Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice.
TLDR
6',7'-Dihydroxybergamottin is a potent inhibitor of CYP3A activity, accounts for the difference in inhibition between grapefruit Juice and orange juice in vitro, and may be primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. Expand
Vancomycin Pharmacokinetics in a Patient Population: Effect of Age, Gender, and Body Weight
TLDR
Regression analysis indicated that V was more predictable in women than in men and that vancomycin distributed into excess body weight (EBW) to a greater extent in women, and dosing of vancomYcin may be improved by adjusting initial estimates of V for patient age, gender, and obesity. Expand
Recent Advances: the Cytochrome P450 Enzymes
TLDR
The ability of new drugs to inhibit or induce the activity of the key P450 enzymes must be known if the ability to take full advantage of the current knowledge of how the cytochrome P450 system works is taken. Expand
Drug Removal by Plasmapheresis: An Evidence‐Based Review
TLDR
Data regarding drug removal during plasmapheresis is sparse and important issues are drug extraction during plasma exchange with chemotherapy, as well as drug classes such as antiinfectives, anticoagulants, antiepileptics, cardiovascular agents, and immunosuppressants. Expand
Frequency and Type of Epidermal Growth Factor Receptor Mutations in African Americans with Non-small Cell Lung Cancer
TLDR
Clinicians should not use race as a clinical decision parameter for the use of EGFR-tyrosine kinase inhibitors, as the results indicate that African Americans with NSCLC harbor somatic EGFR mutations at a frequency similar to whites withNSCLC. Expand
Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H).
TLDR
Improvements in QoL, as measured by the QLS-H, are maintained during long-term GH replacement therapy of adults with GHD, and the Q LS-H is a useful tool for evaluatingQoL in hypopituitary patients treated in clinical practice. Expand
Behavioral effects of a single neuroleptic treatment grow with the passage of time
TLDR
The principal finding of this manuscript is that the incidence of catalepsy observed in the rat after a single administration of low, clinically relevant doses of the dopamine receptor antagonists and antipsychotic agents grows over time such that one re-exposure to the same compound up to 8 weeks later results in a marked enhancement of this response. Expand
Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice.
TLDR
It is suggested that grapefruit juice inhibits CYP3A activity in vitro and that neither naringin nor naringenin are primarily responsible for this effect. Expand
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