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Hematocrit, Volume Expander, Temperature, and Shear Rate Effects on Blood Viscosity
Our goal was to determine and predict the effects of temperature, shear rate, hematocrit, and different volume expanders on blood viscosity in conditions mimicking deep hypothermia for cardiac… Expand
Theoretical and experimental intravascular gas embolism absorption dynamics.
Multifocal cerebrovascular gas embolism occurs frequently during cardiopulmonary bypass and is thought to cause postoperative neurological dysfunction in large numbers of patients. We developed a… Expand
Polidocanol for endovenous microfoam sclerosant therapy
- D. Eckmann
- Expert opinion on investigational drugs
- 25 November 2009
Background: Polidocanol is a liquid surfactant having endothelial cell lytic properties. In the form of a controlled, dispensed microfoam it is administered endovenously as a sclerosing agent in the… Expand
Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers.
- A. J. Calderon, T. Bhowmick, +5 authors S. Muro
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 February 2011
Targeting of drug carriers to cell adhesion molecules expressed on endothelial cells (ECs) may improve treatment of diseases involving the vascular endothelium. This is the case for carriers targeted… Expand
Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells.
Vascular drug delivery by administration of carriers targeted to endothelial surface determinants, such as intercellular adhesion molecule (ICAM-1), holds considerable promise to improve disease… Expand
A front tracking method for a deformable intravascular bubble in a tube with soluble surfactant transport
Based on a front tracking scheme, we have presented a comprehensive algorithm for the study of a deformable bubble moving in a tube in the presence of a soluble or an insoluble surfactant. Expand
Model Predictions of Gas Embolism Growth and Reabsorption during Xenon Anesthesia
Background It is not readily obvious whether an intravascular bubble will grow or shrink in a particular tissue bed. This depends on the constituent gases initially present in the bubble, the… Expand
Nanogel Carrier Design for Targeted Drug Delivery.
- D. Eckmann, R. Composto, A. Tsourkas, V. Muzykantov
- Computer Science, Medicine
- Journal of materials chemistry. B
- 5 November 2014
We address key chemical and biological aspects of nanogel drug carrier design, including ease of synthesis, controllable swelling and viscoelasticity. Expand
Surfactants Reduce Platelet–Bubble and Platelet–Platelet Binding Induced by In Vitro Air Embolism
Background:The effect of gas bubbles on platelet behavior is poorly characterized. The authors assessed platelet–bubble and platelet–platelet binding in platelet-rich plasma in the presence and… Expand
Numerical study of wall effects on buoyant gas-bubble rise in a liquid-filled finite cylinder.
- K. Mukundakrishnan, S. Quan, D. Eckmann, P. Ayyaswamy
- Physics, Medicine
- Physical review. E, Statistical, nonlinear, and…
- 19 September 2007
The wall effects on the axisymmetric rise and deformation of an initially spherical gas bubble released from rest in a liquid-filled, finite circular cylinder are numerically investigated. The bulk… Expand