• Publications
  • Influence
Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1.
Immunocytochemistry on serial paraffin sections was used to monitor the production dynamics of cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma and TNF-alpha) and viral antigens in the trigeminalExpand
Conclusions of the corneal transplant follow up study
While confirming possible benefits of Hla-A and B matching, the expense and delay involved in awaiting matched HLA-DR tissue is unlikely to be justified and donor factors are unrelated to graft outcome following screening of tissue by eye banks. Expand
Human herpesviruses in the cornea
A combination of PCR and IHC increases the specificity for the diagnosis of HSK to 97%. Expand
Acanthamoeba keratitis: risk factors and outcome.
Most patients with Acanthamoeba keratitis can now expect a good visual result and cure by medical therapy alone is favoured by early diagnosis, and during the course of the series the average diagnostic delay has fallen markedly. Expand
Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.
A combination of PLP fixation and low-temperature paraffin embedding permits detection of the major types of immune cell in rat and mouse tissues while maintaining good morphology, particularly in diseased, damaged, or delicate tissues. Expand
Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1
Large numbers of immune cell infiltrating the trigeminal ganglion and extensive expression of MHC class II were seen well into the phase of virus latency; the significance of this is discussed. Expand
Ganciclovir ophthalmic gel (Virgan; 0.15%) in the treatment of herpes simplex keratitis.
The findings support the efficacy of ganciclovir gel in the treatment of ulcerative herpes simplex keratitis and demonstrate its superior local tolerance when compared with acyclovir ointment. Expand
Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.
Review of the relative efficacy of topical ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis showed that both treatment modalities were equally effective in their ability to heal the viral induced corneal ulceration. Expand
The Bristol Shared Care Glaucoma Study: reliability of community optometric and hospital eye service test measures
Trained community optometrists are able to make reliable measurements of the factors important in the assessment of glaucoma patients and glau coma suspects, and the visual field was found to be the most reliable measurement and the cup to disc ratio the least. Expand
Changes in the collagenous matrix of the aging human lamina cribrosa.
Age-related changes in collagen composition imply that the mechanical properties of the lamina cribrosa are altered, resulting in a stiffer, less resilient structure with age, which may contribute to the increased susceptibility of the elderly to axonal damage in chronic open angle glaucoma. Expand