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Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice.
Two macrocyclic 14C-pyrrolizidine alkaloids (PA's), senecionine an seneciphylline, were studied regarding the distribution, excretion, transfer into milk, and covalent binding to hepaticExpand
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Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on aminopyrine N-demethylase activity on the rat liver S-10 fraction.
The effects of individual pyrrolizidine alkaloids on the mixed-function oxidase (MFO) enzyme aminopyrine N-demethylase were determined in rat liver 10 000 X g supernatant. The pyrrolizidineExpand
  • 10
  • 1
A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.
The in vitro mouse hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid senecionine was studied by high-performance liquid chromatography. A muBondapak-C18 reverse-phase system wasExpand
  • 15
Development of an Acute Model for the Study of Chloromethanediphosphonate Nephrotoxicity
Chloromethanediphosphonate (Cl2MDP), a cation chelator, is used as a therapeutic for hypercalcemia of malignancy. Cl2MDP exhibits nephrotoxic potential. Thus, a useful model has been developed toExpand
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Risedronate treatment does not increase microdamage in the canine femoral neck.
Cortical and trabecular bone from the femoral neck of 24 adult female beagle dogs was examined for microdamage following 2 years of treatment with risedronate (NE-58095). Specimens of the femoralExpand
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The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-funcion oxidase system.
A model system to detect the toxicity of pyrrolizidine alkaloids (PAs) was explored. Using the liver S-10 fraction, the effect of PAs on aniline hydroxylase and aminopyrine N-demethylase wasExpand
  • 5
Flight Test Demonstration of Automatic Landings Based on Microwave Landing System Guidance.
Abstract : This report describes the USAF participation in the gathering of data for the United States submission to the International Civil Aviation Organization of a Non-Visual Precision ApproachExpand
A Probabilistic Approach to Life Management for Auxiliary Power Units
Component fatigue life is a major concern in the design of gas turbine Auxiliary Power Units as it directly influences the reliability and life cycle cost of the end product. Accordingly, there isExpand